2-[3-[Tert-butyl(dimethyl)silyl]oxyhept-6-en-1-ynyl]cyclopentene-1-carbaldehyde | 1450835-47-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 2-[3-[Tert-butyl(dimethyl)silyl]oxyhept-6-en-1-ynyl]cyclopentene-1-carbaldehyde
• 英文别名: 2-[3-[tert-butyl(dimethyl)silyl]oxyhept-6-en-1-ynyl]cyclopentene-1-carbaldehyde
• CAS: 1450835-47-8
• 化学式: C₁₉H₃₀O₂Si
• 分子量: 318.531
• InChiKey: DFXHFKBTPCQGQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.03
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[3-[Tert-butyl(dimethyl)silyl]oxyhept-6-en-1-ynyl]cyclopentene-1-carbaldehyde 在 platinum(II) chloride 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以98%的产率得到1-[Tert-butyl(dimethyl)silyl]oxy-1,2,3,3a,4,6,7,8-octahydrocyclopenta[g]azulen-5-one
  参考文献：
  名称：

  Selective Construction of Aliphatic Polycycles Utilizing Platinum-Catalyzed Cyclization of 2-(Enynyl)cycloalkenals

  摘要：

  An efficient method for the selective construction of aliphatic polycycles through platinum-catalyzed cyclization of 2-(enynyl) cycloalkenals has been developed by considering electronic (ligand) and structural (olefinic tether) effect. The presence or absence of ligand and the length of olefinic tether determine the course of the reaction after the formation of platinum-carbene complex, so that four types of aliphatic polycycles can be formed selectively.

  DOI：

  10.1055/s-0033-1338805
• 作为产物：
  描述：

  环戊酮 在 三溴化磷 、 钯 作用下， 生成 2-[3-[Tert-butyl(dimethyl)silyl]oxyhept-6-en-1-ynyl]cyclopentene-1-carbaldehyde
  参考文献：
  名称：

  Selective Construction of Aliphatic Polycycles Utilizing Platinum-Catalyzed Cyclization of 2-(Enynyl)cycloalkenals

  摘要：

  An efficient method for the selective construction of aliphatic polycycles through platinum-catalyzed cyclization of 2-(enynyl) cycloalkenals has been developed by considering electronic (ligand) and structural (olefinic tether) effect. The presence or absence of ligand and the length of olefinic tether determine the course of the reaction after the formation of platinum-carbene complex, so that four types of aliphatic polycycles can be formed selectively.

  DOI：

  10.1055/s-0033-1338805