2-(Piperid-2-yl)-propionsaeure | 90205-07-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-(Piperid-2-yl)-propionsaeure
• 英文别名: 2-Piperidin-2-ylpropanoic acid
• CAS: 90205-07-5
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: VPFKXQPGMUEDNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] HIGHLY SELECTIVE NOVEL AMIDATION METHOD<br/>[FR] PROCÉDÉ D'UNE NOUVELLE AMIDATION TRÈS SÉLECTIVE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2005121133A1

  公开（公告）日：2005-12-22

  The present invention provides an industrial production method with a short process having a high yield of an aliphatic cyclic carboxamide having carboxyl group, which comprises reacting functional group-selectively using an inexpensive condensing agent without protecting the carboxyl group by esterification, that is, reacting carboxylic acid anhydride obtained by reacting carboxylic acid and tertiary carboxylic acid halide with aliphatic cyclic secondary amine having carboxyl group.

  本发明提供了一种工业生产方法，该方法具有短流程、高产率，用于制备含有羧基的脂肪族环状酰胺，其特点在于使用廉价的缩合剂对功能团进行选择性反应，而不通过酯化保护羧基，即通过将由羧酸与叔羧酸卤化物反应得到的羧酸酐与含有羧基的脂肪族环状仲胺进行反应。
• [EN] GLYCINE METABOLISM MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DU MÉTABOLISME DE LA GLYCINE ET LEURS UTILISATIONS
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2018021977A1

  公开（公告）日：2018-02-01

  The present invention relates to a compound of general formula (I) and/or its solvates, hydrates and pharmaceutically acceptable salts, which are modulators of glycine metabolism. The present invention also relates to the methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with glycine metabolism or a pathway where glycine decarboxylase (GLDC, or glycine cleavage system) plays a role. In a preferred embodiment the disorders/conditions/disease is cancer, inflammatory conditions, Alzheimer's disease, metabolic disorders and CNS disorders.

  本发明涉及一般式(I)的化合物及/或其溶剂合物、水合物和药学上可接受的盐，这些化合物是甘氨酸代谢调节剂。本发明还涉及其制备方法、含有这些化合物的药物组合物以及这些化合物在治疗涉及或与甘氨酸代谢或甘氨酸脱羧酶（GLDC，或甘氨酸裂解系统）发挥作用的病症/疾病/疾病的用途。在一个首选实施例中，疾病/疾病是癌症、炎症性疾病、阿尔茨海默病、代谢性疾病和中枢神经系统疾病。
• Highly Selective Novel Amidation Method
  申请人：Inagaki Atsushi

  公开号：US20070238721A1

  公开（公告）日：2007-10-11

  The present invention provides an industrial production method with a short process having a high yield of an aliphatic cyclic carboxamide having carboxyl group, which comprises reacting functional group-selectively using an inexpensive condensing agent without protecting the carboxyl group by esterification, that is, reacting carboxylic acid anhydride obtained by reacting carboxylic acid and tertiary carboxylic acid halide with aliphatic cyclic secondary amine having carboxyl group.

  本发明提供了一种工业生产方法，该方法具有短工艺流程，高产率，用廉价的缩合剂进行功能基选择性反应，不需要通过酯化来保护羧基，即将羧酸和三级羧酸卤化物反应得到羧酸酐，然后与具有羧基的脂环状二级胺反应。
• Tetrapyrrole carboxylic acid derivatives for diagnosis and/or therapy of arthritis
  申请人：NIPPON PETROCHEMICALS CO., LTD.

  公开号：EP0629409A1

  公开（公告）日：1994-12-21

  A method and medical agents for the photodynamic diagnosis or photodynamic therapy of rheumatoid arthritis of mammals, which agent comprises at least one member of fluorescent compounds selected from the group consisting of tetrapyrrole carboxylic acids having at least one carboxyl group, corresponding di- or tetrahydrotetrapyrrole carboxylic acids, and mono-, di- or polyamides of the tetrapyrrole carboxylic acids with amino-mono- or dicarboxylic acids and their salts.

  一种用于哺乳动物类风湿性关节炎光动力学诊断或光动力学治疗的方法和医用药剂，该药剂包括至少一种从四吡咯烷羧酸、对应的二或四氢四吡咯烷羧酸和四吡咯烷羧酸的单、二或多酰胺以及它们的氨基单或二羧酸盐中选择的荧光化合物成员。
• [EN] PYRAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF ANEMIA<br/>[FR] COMPOSES DE PYRAZOLOPYRIDINE DESTINES AU TRAITEMENT DE L'ANEMIE
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：WO1993025205A1

  公开（公告）日：1993-12-23

  (EN) The present invention relates to a pharmaceutical composition for the prevention and/or the treatment of anemia in a human being or an animal which comprises, as an active ingredient, a pyrazolopyridine compound of formula (I) wherein R1 is lower alkyl, etc, R2 is a group of formula (II) (wherein R4 is protected amino, etc, and R5 is hydrogen, etc); etc, and R3 is hydrogen, etc, or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable carrier or excipient, etc.(FR) Composition pharmaceutique destinée à la prévention et/ou au traitement de l'anémie chez l'être humain ou chez l'animal. Cette composition comprend comme ingrédient actif un composé de pyrazolopyridine de la formule (I), dans laquelle R1 est un alkyle inférieur, etc.; R2 est un groupe de la formule (II), dans laquelle R4 est un amino protégé, etc. et R5 est l'hydrogène, etc.; etc. et R3 est l'hydrogène, etc.; ou un sel pharmaceutiquement acceptable de ce composé, mélangé à un excipient pharmaceutiquement acceptable, etc.

  本发明涉及一种药物组合物，用于预防和/或治疗人类或动物的贫血，其作为活性成分包含式（I）的吡唑啉并吡啶化合物，其中R1是低碳基等，R2是式（II）的基团（其中R4是保护氨基等，R5是氢等）等，R3是氢等，或其药学上可接受的盐与药学上可接受的载体或赋形剂等混合物。