2-Azaphenyl-indolizidin | 22820-97-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Azaphenyl-indolizidin
• 英文别名: 2-phenyl-octahydro-imidazo[1,5-a]pyridine；2-phenyl-3,5,6,7,8,8a-hexahydro-1H-imidazo[1,5-a]pyridine
• CAS: 22820-97-9
• 化学式: C₁₃H₁₈N₂
• 分子量: 202.299
• InChiKey: ZYMFOWJCDCWEAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HYDANTOIN DERIVATIVE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USING SAME
  申请人：GPI NIL Holdings, Inc.

  公开号：EP1244670A1

  公开（公告）日：2002-10-02
• METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY
  申请人：GUILFORD PHARMACEUTICALS INC.

  公开号：EP1404325A2

  公开（公告）日：2004-04-07
• [EN] HYDANTOIN DERIVATIVE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USING SAME<br/>[FR] COMPOSES A BASE DE DERIVES D'HYDANTOÏNE, COMPOSITIONS PHARMACEUTIQUES, ET MODES D'UTILISATION
  申请人：GUILFORD PHARM INC

  公开号：WO2001046195A1

  公开（公告）日：2001-06-28

  The present invention relates generally to novel hydantoin derivative compounds, pharmaceutical compositions containing such compounds, and methods for their use in preventing and/or treating neurological disorders, including physically damaged nerves and neurodegenerative diseases; for treating alopecia and promoting hair growth; for treating vision disorders and/or improving vision; for treating memory impairment and/or enhancing memory performance; and for treating sensorineural hearing loss by administering such compounds.
• [EN] METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY<br/>[FR] PROCEDE DE TRAITEMENT D'ACCIDENTS NERVEUX ENTRAINES PAR UNE OPERATION
  申请人：GUILFORD PHARM INC

  公开号：WO2002096420A2

  公开（公告）日：2002-12-05

  The present invention relates generally to methods for treating or preventing nerve injury in a warm-blooded animal caused as a consequence of surgery by administering neurotrophic compounds described below. The invention relates more specifically to methods for treating or preventing nerve injury caused as a consequence of prostate surgery as well as erectile dysfunction.