2,3-Trimethylen-piperidon-(6) | 83691-13-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2,3-Trimethylen-piperidon-(6)
• 英文别名: 2-azabicyclo-[4.3.0]-nonane-3-one；(4aR,7aR)-1,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyridin-2-one；1,3,4,4a,5,6,7,7a-octahydrocyclopenta[b]pyridin-2-one
• CAS: 83691-13-8
• 化学式: C₈H₁₃NO
• mdl: MFCD19218312
• 分子量: 139.197
• InChiKey: CMIHVRWCPABPKH-UHFFFAOYSA-N

物化性质

• 沸点：
  308.5±11.0 °C(Predicted)
• 密度：
  1.044±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Bicycloloactam compounds, use thereof and intermediates for preparing thereof
  申请人：Taiho Pharmaceutical Company Limited

  公开号：US20020099048A1

  公开（公告）日：2002-07-25

  A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly diminished in side effects such as hypnotic, muscle relaxant and sedative effects 1 A bicyclolactam derivative represented by the following formula (1) is also disclosed, and is useful as an effective component of an anxiolytic agent 2

  公开了一种具有优异的抗焦虑效果、高度安全并且可用作药物有效成分的环状内酰胺化合物，其化学式为（1），该药物成分的副作用如催眠、肌肉松弛和镇静效应等大大降低。同时，还公开了以下化学式（1）所代表的环状内酰胺衍生物，可用作抗焦虑剂的有效成分。
• BICYCLOLACTAM DERIVATIVE
  申请人：TAIHO PHARMACEUTICAL COMPANY LIMITED

  公开号：EP0466933A1

  公开（公告）日：1992-01-22

  A bicyclolactam derivative of general formula (1), which is quite useful for treating senile dementia, or improving the brain function and activating and protecting the brain metabolism, wherein R represents benzoyl which may be substituted with halogen, lower alkyl, lower alkoxy, nitro, cyano or amino; ℓ is 1 or 2; m is 0 or 1; and n is 0, 1 or 2, provided that m and n are not 0 at the same time.

  一种通式（1）的双环内酰胺衍生物，对治疗老年痴呆症或改善脑功能、激活和保护脑代谢非常有用，其中 R 代表可被卤素、低级烷基、低级烷氧基、硝基、氰基或氨基取代的苯甲酰基；ℓ 为 1 或 2；m 为 0 或 1；n 为 0、1 或 2，条件是 m 和 n 不能同时为 0。
• Bicyclolactam derivatives for improving cerebral functions
  申请人：TAIHO PHARMACEUTICAL COMPANY LIMITED

  公开号：EP0668268A2

  公开（公告）日：1995-08-23

  Disclosed is a bicyclolactam derivative represented by the formula wherein R is a benzoyl group which may be substituted with halogen, lower alkyl, lower alkoxy, nitro, cyano or amino; I is 1 or 2; m is 0 or 1; and n is 0 or 1, provided that m and n are not 0 at the same time, which has a cerebral function improving effect, cerebral metabolism activating or anoxic brain damage protecting effect and effect against senile dementia.

  本发明公开了一种双环内酰胺衍生物，由式表示 其中，R 是苯甲酰基，可被卤素、低级烷基、低级烷氧基、硝基、氰基或氨基取代；I 是 1 或 2；m 是 0 或 1；n 是 0 或 1，但 m 和 n 不能同时为 0，该衍生物具有改善脑功能、激活脑代谢或缺氧性脑损伤保护作用以及抗老年痴呆作用。
• ANXIOLYTIC AGENT
  申请人：TAIHO PHARMACEUTICAL COMPANY LIMITED

  公开号：EP0713702A1

  公开（公告）日：1996-05-29

  A bicyclolactam derivative represented by general formula (1) and useful as the active ingredient of an anxiolytic agent, wherein R¹ represents hydrogen or hydroxy; R² represents optionally substituted benzoyl; l represents 1 or 2; m represents 0 or 1; and n represents 0, 1 or 2, provided the case where both of m and n represent 0 simultaneously is excluded.

  由通式(1)表示并可用作抗焦虑剂活性成分的双环内酰胺衍生物，其中 R¹ 代表氢或羟基；R² 代表任选取代的苯甲酰基；l 代表 1 或 2；m 代表 0 或 1；n 代表 0、1 或 2，但不包括 m 和 n 同时代表 0 的情况。
• SUBSTITUTED UREA DERIVATIVES AND PHARMACEUTICAL USES THEREOF
  申请人：SUNSHINE LAKE PHARMA CO., LTD.

  公开号：US20170114032A1

  公开（公告）日：2017-04-27

  Provided herein are novel substituted urea derivatives, and pharmaceutical compositions thereof. Also provided herein are uses of the compounds or pharmaceutical compositions thereof for preventing, managing, treating or lessening a proliferative disease, and modulating the activity of protein kinase.