4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-N-(4-octyl-3-(trifluoromethyl)phenyl)thiazol-2-amine | 1088699-95-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡啶类
• 英文名称: 4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-N-(4-octyl-3-(trifluoromethyl)phenyl)thiazol-2-amine
• 英文别名: N-[4-octyl-3-(trifluoromethyl)phenyl]-4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-thiazol-2-amine
• CAS: 1088699-95-9
• 化学式: C₂₄H₂₆F₃N₅S
• 分子量: 473.565
• InChiKey: UBHZBZAINUCGMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  83.4
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• HETEROARYL SUBSTITUTED THIAZOLES
  申请人：Wang Xiangzhu

  公开号：US20090041720A1

  公开（公告）日：2009-02-12

  The invention provides heteroaryl substituted thiazolo compounds of Formula I and II and pharmaceutically acceptable salts thereof. The variables A and R 3 to R 7 are defined herein. The invention also includes methods for preparing compounds and salts of Formula I and II. The present invention also includes pharmaceutical compositions containing heteroaryl substituted thiazolo compounds and methods for using heteroaryl substituted thiazolo compounds, including methods for using the compounds in the treatment of hepatitis C virus.
• US8183263B2
  申请人：——

  公开号：US8183263B2

  公开（公告）日：2012-05-22