4-(8-{4-[1-(2-fluoroethyl)piperidin-4-yl]phenylamino}imidazo[1,2-a]pyridin-5-yl)-1H-pyridin-2-one | 1031285-90-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(8-{4-[1-(2-fluoroethyl)piperidin-4-yl]phenylamino}imidazo[1,2-a]pyridin-5-yl)-1H-pyridin-2-one
• 英文别名: 4-[8-[4-[1-(2-fluoroethyl)piperidin-4-yl]anilino]imidazo[1,2-a]pyridin-5-yl]-1H-pyridin-2-one
• CAS: 1031285-90-1
• 化学式: C₂₅H₂₆FN₅O
• 分子量: 431.513
• InChiKey: UINIVVKOUQOSKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases
  申请人：Edwards Paul John

  公开号：US20090048245A1

  公开（公告）日：2009-02-19

  Novel imidazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

  本发明揭示了一种具有以下公式表示的新型咪唑吡啶化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗哺乳动物，包括人类的多种病症，包括但不限于ECM降解、关节降解和/或炎症等。
• IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
  申请人：EDWARDS Paul John

  公开号：US20120010206A1

  公开（公告）日：2012-01-12

  Novel imidazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

  本发明揭示了一种具有以下公式表示的新型咪唑吡啶化合物：这些化合物可以制备为药物组合物，并可用于预防和治疗哺乳动物包括人类的各种疾病，包括但不限于ECM降解，关节降解和/或炎症等。
• US7951818B2
  申请人：——

  公开号：US7951818B2

  公开（公告）日：2011-05-31
• [EN] IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES<br/>[FR] COMPOSÉS D'IMIDAZOLOPYRIDINE POUR LE TRAITEMENT DES MALADIES DÉGÉNÉRATIVES ET INFLAMMATOIRES
  申请人：GALAPAGOS NV

  公开号：WO2008065199A1

  公开（公告）日：2008-06-05

  [EN] Novel imidazolopyridine compounds are disclosed that have a formula represented by Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.
  [FR] L'invention concerne de nouveaux composés d'imidazolopyridine dont la formule est représentée par la formule (I). Ces composés peuvent être préparés sous forme de compositions pharmaceutiques, et peuvent être utilisés pour la prévention et le traitement de divers troubles chez les mammifères, y compris l'homme, notamment, à titre d'exemples sans valeur limitative, la dégradation de la matrice extracellulaire, la dégradation des articulations et/ou les inflammations, etc.