4-(propionylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester | 947139-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-(propionylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl 4-[(propanoylamino)methyl]piperidine-1-carboxylate
• CAS: 947139-43-7
• 化学式: C₁₄H₂₆N₂O₃
• mdl: MFCD24392258
• 分子量: 270.372
• InChiKey: UWEMLTJMXGJHMC-UHFFFAOYSA-N

物化性质

• 沸点：
  420.1±18.0 °C(Predicted)
• 密度：
  1.035±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(propionylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 反应 3.0h， 以74%的产率得到N-(Piperidin-4-ylmethyl)propionamide
  参考文献：
  名称：

  Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers

  摘要：

  A series of 2-oxopiperazine, 4-aminomethyl-, 3-amino- and 3-aminomethylpiperidine analogues of DM235 (sunifiram) and MN19 (sapunifiram), two previously reported potent cognition-enhancers, have been synthesized and tested in the mouse passive-avoidance test. The compounds display minimal effective doses in the range 0.3-10 mg/kg. Although the new substances do not show improved activity when compared to the parent compounds, some useful information has been obtained to understand structure-activity relationships. In addition, the 3-aminopiperidine moiety appears to be a promising scaffold to synthesize new drugs endowed with cognition-enhancing activity. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.050
• 作为产物：
  描述：

  丙酰氯 、 1-叔丁氧羰基-4-氨甲基哌啶 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 48.0h， 以46%的产率得到4-(propionylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers

  摘要：

  A series of 2-oxopiperazine, 4-aminomethyl-, 3-amino- and 3-aminomethylpiperidine analogues of DM235 (sunifiram) and MN19 (sapunifiram), two previously reported potent cognition-enhancers, have been synthesized and tested in the mouse passive-avoidance test. The compounds display minimal effective doses in the range 0.3-10 mg/kg. Although the new substances do not show improved activity when compared to the parent compounds, some useful information has been obtained to understand structure-activity relationships. In addition, the 3-aminopiperidine moiety appears to be a promising scaffold to synthesize new drugs endowed with cognition-enhancing activity. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.050

文献信息

• 1-PHENETHYLPIPERIDINE DERIVATIVES AND THEIR USE AS OPIOID RECEPTOR LIGANDS
  申请人：Peters Dan

  公开号：US20100234427A1

  公开（公告）日：2010-09-16

  This invention relates to novel 1-phenethylpiperidine derivatives useful as opioid receptor ligands. More specifically, the invention provides compounds useful as μ opioid receptor ligands. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of pain, and to pharmaceutical compositions comprising the compounds of the invention.

  本发明涉及一种新型的1-苯乙基哌啶衍生物，其可用作阿片受体配体。更具体地，本发明提供了一种有用的μ阿片受体配体化合物。在其他方面，本发明涉及使用这些化合物的治疗方法，例如用于治疗疼痛，并涉及包含本发明化合物的制药组合物。
• WO2007/93603
  申请人：——

  公开号：——

  公开（公告）日：——