4-fluoro-2,2,6,6-tetradeuteropiperidin-1-amine hydrochloride | 1001338-25-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-fluoro-2,2,6,6-tetradeuteropiperidin-1-amine hydrochloride
• 英文别名: 2,2,6,6-Tetradeuterio-4-fluoropiperidin-1-amine;hydrochloride
• CAS: 1001338-25-5
• 化学式: C₅H₁₁FN₂*ClH
• 分子量: 158.583
• InChiKey: UBMNAOGIDKOUSZ-URZLSVTISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.72
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Biphenyl-pyrazolecarboxamide compounds
  申请人：Tung Roger

  公开号：US20070066657A1

  公开（公告）日：2007-03-22

  The present invention relates to biphenyl-pyrazole compounds and in particular biphenyl-pyrazolecarboxamides. The invention further provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by antagonism or inverse agonism of the CB 1 receptor, such as obesity, smoking cessation, and normalization of blood lipid composition.

  本发明涉及联苯基吡唑化合物，特别是联苯基吡唑羧酰胺。该发明还提供了包含本发明化合物的组合物，以及利用这些组合物在治疗疾病和状况方面的方法，这些疾病和状况通过CB1受体的拮抗或逆作用有益治疗，如肥胖、戒烟和血脂组成的正常化。
• BIPHENYL-PYRAZOLECARBOXAMIDE COMPOUNDS
  申请人：Tung Roger

  公开号：US20090258902A1

  公开（公告）日：2009-10-15

  The present invention relates to biphenyl-pyrazole compounds and in particular biphenyl-pyrazolecarboxamides. The invention further provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by antagonism or inverse agonism of the CB 1 receptor, such as obesity, smoking cessation, and normalization of blood lipid composition.

  本发明涉及联苯基吡唑化合物，特别是联苯基吡唑羧酰胺。本发明还提供了包含本发明化合物的组合物，并将这种组合物用于治疗通过CB1受体拮抗或反向激动作用有益治疗的疾病和病症，如肥胖症、戒烟和正常化血脂组成。
• US7514068B2
  申请人：——

  公开号：US7514068B2

  公开（公告）日：2009-04-07
• [EN] BIPHENYL-PYRAZOLECARBOXAMIDE COMPOUNDS<br/>[FR] COMPOSES DE BIPHENYL-PYRAZOLECARBOXAMIDE
  申请人：CONCERT PHARMACEUTICALS INC

  公开号：WO2007033366A2

  公开（公告）日：2007-03-22

  (EN) The present invention relates to biphenyl-pyrazole compounds and in particular biphenyl-pyrazolecarboxamides. The invention further provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by antagonism or inverse agonism of the CB1 receptor, such as obesity, smoking cessation, and normalization of blood lipid composition.(FR) L'invention se rapporte à des composés biphényl-pyrazole et en particulier à des biphényl-pyrazolecarboxamides. L'invention concerne également des compositions contenant un composé selon l'invention, et l'utilisation de ces composition dans des méthodes de traitement de pathologies et d'états améliorés par un traitement antagoniste ou antagoniste inverse du récepteur CB1, tels que l'obésité, le sevrage du tabac, et la normalisation de la composition des lipides sanguins.