3-{-4-[cyclopropyl-(3-trifluoromethyl-benzenesulfonyl)-amino]-piperidin-1-yl}-5-fluoro-benzoic acid ethyl ester | 1137153-52-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-{-4-[cyclopropyl-(3-trifluoromethyl-benzenesulfonyl)-amino]-piperidin-1-yl}-5-fluoro-benzoic acid ethyl ester
• 英文别名: Ethyl 3-[4-[cyclopropyl-[3-(trifluoromethyl)phenyl]sulfonylamino]piperidin-1-yl]-5-fluorobenzoate
• CAS: 1137153-52-6
• 化学式: C₂₄H₂₆F₄N₂O₄S
• 分子量: 514.541
• InChiKey: STKNUDCSGWFUBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  75.3
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• Benzenesulfonamide Compounds and the Use Thereof
  申请人：Shao Bin

  公开号：US20100311792A1

  公开（公告）日：2010-12-09

  The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R 1 , R 2 , R 3 , Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及式(I)的氮杂环化合物，包括氮杂环丙烷基、吡咯烷基、哌啶基和六氢氮杂环己烷基化合物及其药学上可接受的盐、前药或溶剂化物，其中R1、R2、R3、Z和q如规范中所述。本发明还涉及使用式(I)的化合物治疗对钙通道封锁敏感的疾病，尤其是N型钙通道。本发明的化合物特别适用于治疗疼痛。
• US8765736B2
  申请人：——

  公开号：US8765736B2

  公开（公告）日：2014-07-01
• [EN] BENZENESULFONAMIDE COMPOUNDS AND THE USE THEREOF<br/>[FR] COMPOSÉS BENZÈNESULFONAMIDES ET LEURS UTILISATIONS
  申请人：PURDUE PHARMA LP

  公开号：WO2009040659A2

  公开（公告）日：2009-04-02

  The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1, R2, R3, Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.