2,2-Dimethyl-propionic acid (2S,3S,4R,5S)-3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2,4-dimethyl-oct-7-enyl ester | 310901-17-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 2,2-Dimethyl-propionic acid (2S,3S,4R,5S)-3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2,4-dimethyl-oct-7-enyl ester
• CAS: 310901-17-8
• 化学式: C₂₁H₄₂O₄Si
• 分子量: 386.648
• InChiKey: MDDXDBZPENSMHD-MHORFTMASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.18
• 重原子数：
  26.0
• 可旋转键数：
  9.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  55.76
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-propionic acid (2S,3S,4R,5S)-3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2,4-dimethyl-oct-7-enyl ester 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以92%的产率得到2,2-Dimethyl-propionic acid (2S,3S,4R,5S)-3,5-dihydroxy-2,4-dimethyl-oct-7-enyl ester
  参考文献：
  名称：

  Desymmetrization of meso-Dialdehydes with Optically Active Cyclopentadienyldialkoxyallyltitanium Complexes

  摘要：

  [GRAPHICS]Optically active cyclopentadienyldialkoxyallyltitanium complexes have been employed for the desymmetrization of meso-dialdehydes. Allylation of these dialdehydes and subsequent oxidation afford chiral lactones with good diastereoselectivity and excellent enantioselectivity.

  DOI：

  10.1021/ol0057434
• 作为产物：
  描述：

  (3R,4R,5R,6S)-6-Allyl-4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-tetrahydro-pyran-2-ol 在 sodium tetrahydroborate 作用下， 以 吡啶 、 甲醇 为溶剂， 生成 2,2-Dimethyl-propionic acid (2S,3S,4R,5S)-3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2,4-dimethyl-oct-7-enyl ester
  参考文献：
  名称：

  Desymmetrization of meso-Dialdehydes with Optically Active Cyclopentadienyldialkoxyallyltitanium Complexes

  摘要：

  [GRAPHICS]Optically active cyclopentadienyldialkoxyallyltitanium complexes have been employed for the desymmetrization of meso-dialdehydes. Allylation of these dialdehydes and subsequent oxidation afford chiral lactones with good diastereoselectivity and excellent enantioselectivity.

  DOI：

  10.1021/ol0057434