| 199480-66-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 199480-66-5
• 化学式: C₄₉H₅₂N₅O₁₉P
• 分子量: 1045.95
• InChiKey: MJUUEUUONDCIHI-PBUNRCBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.39
• 重原子数：
  74.0
• 可旋转键数：
  22.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  303.32
• 氢给体数：
  2.0
• 氢受体数：
  22.0

反应信息

• 作为反应物：
  描述：

  生成 Phosphoric acid (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,4-bis-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester
  参考文献：
  名称：

  The Synthesis of 2′-C-Functionalised Nucleosides for Incorporation into Catalytic RNA

  摘要：

  Five 2'-C-functionalized nucleosides (1-5) have been prepared and incorporated into dinucleoside monophosphates. The effect of the functionality on the stability of the adjacent phosphodiester bond toward hydrolysis by nuclease enzymes and extremes of pH has been assessed.

  DOI：

  10.1080/07328319708006215
• 作为产物：
  描述：

  2'-deoxy-2'-α-C-(acetoxymethyl)uridine 在 吡啶 、 四氮唑 、 二异丙基铵盐四氮唑 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 1.5h， 生成
  参考文献：
  名称：

  The Synthesis of 2′-C-Functionalised Nucleosides for Incorporation into Catalytic RNA

  摘要：

  Five 2'-C-functionalized nucleosides (1-5) have been prepared and incorporated into dinucleoside monophosphates. The effect of the functionality on the stability of the adjacent phosphodiester bond toward hydrolysis by nuclease enzymes and extremes of pH has been assessed.

  DOI：

  10.1080/07328319708006215

文献信息

• The synthesis of 2′-homouridine, its incorporation into a dinucleoside monophosphate and hydrolytic behaviour of the dimer
  作者：John B.J. Pavey、Anthony J. Lawrence、Andrew J. Potter、Richard Cosstick、Ian A. O'Neil

  DOI：10.1016/s0040-4039(98)01478-6

  日期：1998.9

  An efficient route to 2'-homouridine (1), a new nucleoside analogue, is reported that is based on an ene reaction. This nucleoside has been incorporated into a dinucleoside monophosphate and hydrolytic studies on the dimer show that it does not behave like a ribonucleotide. (C) 1998 Elsevier Science Ltd. All rights reserved.