8-isopropyl-2-((R)-piperidin-3-yloxy)-N-(1-(2-(pyrrolidin-1-yl)phenyl)ethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine | 1453475-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 8-isopropyl-2-((R)-piperidin-3-yloxy)-N-(1-(2-(pyrrolidin-1-yl)phenyl)ethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine
• 英文别名: 2-[(3R)-piperidin-3-yl]oxy-8-propan-2-yl-N-[1-(2-pyrrolidin-1-ylphenyl)ethyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine
• CAS: 1453475-80-3
• 化学式: C₂₅H₃₅N₇O
• 分子量: 449.599
• InChiKey: FHRXTOPSGRQHCD-MUMRKEEXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  79.6
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] PHARMACEUTICALLY ACTIVE PYRAZOLO-TRIAZINE DERIVATIVES<br/>[FR] DÉRIVÉS PYRAZOLO-TRIAZINE PHARMACEUTIQUEMENT ACTIFS
  申请人：LEAD DISCOVERY CENTER GMBH

  公开号：WO2013128029A1

  公开（公告）日：2013-09-06

  The present invention relates to pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors for a protein kinase.

  本发明涉及吡唑咯[1,5-a][1,3,5]三唑衍生物和/或其药用可接受盐，这些衍生物的用途作为药用活性剂，特别用于预防和/或治疗传染病，包括机会性感染病、免疫性疾病、自身免疫性疾病、心血管疾病、细胞增殖性疾病、炎症、勃起功能障碍和中风，以及含有至少一种所述吡唑咯[1,5-a][1,3,5]三唑衍生物和/或其药用可接受盐的药物组合物。此外，本发明涉及所述吡唑咯[1,5-a][1,3,5]三唑衍生物作为蛋白激酶抑制剂的用途。
• PHARMACEUTICALLY ACTIVE PYRAZOLO-TRIAZINE DERIVATIVES
  申请人：LEAD DISCOVERY CENTER GMBH

  公开号：US20150111873A1

  公开（公告）日：2015-04-23

  Pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors for a protein kinase.
• US9096608B2
  申请人：——

  公开号：US9096608B2

  公开（公告）日：2015-08-04