2-[2-[(3S)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-3-yl]-1,3-thiazol-4-yl]acetic acid | 1000991-55-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-[2-[(3S)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-3-yl]-1,3-thiazol-4-yl]acetic acid
• CAS: 1000991-55-8
• 化学式: C₁₅H₂₂N₂O₄S
• 分子量: 326.417
• InChiKey: LCQFVXHNGVEODD-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Compounds and Compositions as Channel Activating Protease Inhibitors
  申请人：Tully C. David

  公开号：US20070276002A1

  公开（公告）日：2007-11-29

  The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.

  该发明提供了化合物及其药物组合物，这些化合物用于调节通道激活蛋白酶，以及使用这些化合物来治疗、改善或预防与通道激活蛋白酶相关的疾病的方法，包括但不限于前列腺素、PRSS22、TMPRSS11（例如，TMPRSS11B，TMPRSS11E）、TMPRSS2、TMPRSS3、TMPRSS4（MTSP-2）、膜联蛋白（MTSP-1）、CAP2、CAP3、胰蛋白酶、组织蛋白酶A或中性粒细胞弹性蛋白酶。
• COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS
  申请人：Tully David C.

  公开号：US20110177055A1

  公开（公告）日：2011-07-21

  The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase,
• US7939547B2
  申请人：——

  公开号：US7939547B2

  公开（公告）日：2011-05-10
• [EN] COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS<br/>[FR] COMPOSÉS ET COMPOSITIONS INHIBANT LES PROTÉASES ACTIVATRICES DE CANAUX
  申请人：IRM LLC

  公开号：WO2007140117A1

  公开（公告）日：2007-12-06

  [EN] The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.
  [FR] L'invention porte sur des composés et leurs préparations pharmaceutiques modulant les protéases d'activation de canaux et sur des méthodes d'utilisation desdits composés pour traiter, améliorer, ou prévenir un état associé à une protéase d'activation de canaux dont, non limitativement,: la prostasine, la PRSS22, la TMPRSS11 (par exemple TMPRSS11B, TMPRSS11E), la TMPRSS2, la TMPRSS3, la TMPRSS4 (MTSP-2), la matriptase (MTSP-1), la CAP2, la CAP3, la trypsine, la cathepsine A, ou l'élastase neutrophile.