trans-4-tert-Butylcyclohexyl trimethylsilyl ether | 32147-25-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: trans-4-tert-Butylcyclohexyl trimethylsilyl ether
• 英文别名: O-Trimethylsilyl-trans-4-tert.-butyl-cyclohexanol；trans-4-tert-Butylcyclohexyl-triethylsilylether
• CAS: 32147-25-4
• 化学式: C₁₃H₂₈OSi
• 分子量: 228.45
• InChiKey: AQKOPOJURPQAEY-HAQNSBGRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.44
• 重原子数：
  15.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  trans-4-tert-Butylcyclohexanol 、 (E)-(1-methoxyprop-1-enyloxy)trimethylsilane 以 二氯甲烷 为溶剂， 生成 trans-4-tert-Butylcyclohexyl trimethylsilyl ether
  参考文献：
  名称：

  酮甲基三烷基甲硅烷基缩醛可作为醇，羧酸，硫醇和酰胺的有效甲硅烷基化剂

  摘要：

  与烯酮甲基三烷基甲硅烷基乙缩醛的甲硅烷基质子交换反应在温和条件下快速而定量地进行。描述了醇，羧酸，硫醇和酰胺的制备甲硅烷基化。

  DOI：

  10.1016/s0040-4039(01)86575-8

文献信息

• A practical method for activation of commercial lithium hydride: reductive silylation of carbonyl compounds with lithium hydride and chlorotrimethylsilane
  作者：Takeshi Ohkuma、Shohei Hashiguchi、Ryoji Noyori

  DOI：10.1021/jo00080a035

  日期：1994.1

  Commercially available lithium hydride, an essentially inert metal hydride, can be activated as a hydride source by an equimolar amount of chlorotrimethylsilane and a catalytic amount of a Zn salt or Zn powder. Aromatic and aliphatic ketones, as well as nonenolizable aldehydes, are reductively converted to the trimethylsilyl ethers of the corresponding alcohols in high yields by treatment with this reagent system in dichloromethane or toluene at 28 to 40 degrees C for 25-50 h. This procedure has many advantages including the safety and low cost of the reagents and operational simplicity and provides a practical method for carbonyl reduction. X-ray induced Auger electron spectroscopy analysis suggests that a Zn(II)I species is the catalyst of the heterogeneous reaction.
• Activation of Reducing Agents: Sodium Hydride-Containing Complex Reducing Agents; XVII¹. A Very Efficient, One-Pot Reductive Silylation of Saturated or Unsaturated Ketones and Aldehydes
  作者：Jean-Jacques Brunet、Denis Besozzi、Paul Caubère

  DOI：10.1055/s-1982-29912

  日期：——