5-tert-butyl 1-ethyl 3-{[4-(4-fluoropiperidin-1-yl)benzoyl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate | 827318-65-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 5-tert-butyl 1-ethyl 3-{[4-(4-fluoropiperidin-1-yl)benzoyl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate
• 英文别名: 5-O-tert-butyl 1-O-ethyl 3-[[4-(4-fluoropiperidin-1-yl)benzoyl]amino]-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate
• CAS: 827318-65-0
• 化学式: C₂₅H₃₂FN₅O₅
• 分子量: 501.558
• InChiKey: GOSAJKHDHLKIEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS<br/>[FR] ANALOGUES D'AMINOGLYCOSIDES ANTIBACTÉRIENS
  申请人：ACHAOGEN INC

  公开号：WO2009067692A1

  公开（公告）日：2009-05-28

  Compounds of structure (I): having antibacterial activity are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  结构（I）的化合物具有抗菌活性，包括立体异构体、药用可接受的盐和前药，其中Q1、Q2、Q3、R8和R9如本文所定义。还公开了与制备和使用这些化合物相关的方法，以及包含这些化合物的药物组合物。
• Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
  申请人：Fancelli Daniele

  公开号：US20050032839A1

  公开（公告）日：2005-02-10

  Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  本文披露了式(I)及其药学上可接受的盐的吡咯并[3,4-c]吡唑衍生物，以及其制备方法和包含它们的药物组合物；本发明的化合物可能在治疗与蛋白激酶活性失调有关的疾病，如癌症方面有用。
• PYRROLO 3,4-c PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
  申请人：NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：EP1644376B1

  公开（公告）日：2010-09-08
• ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
  申请人：Achaogen, Inc.

  公开号：EP2217610A1

  公开（公告）日：2010-08-18
• US7141568B2
  申请人：——

  公开号：US7141568B2

  公开（公告）日：2006-11-28