N-(4-methoxyphenyl)oxazolo[4,5-b]pyridin-2-amine | 1564283-79-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶唑并吡啶类
• 英文名称: N-(4-methoxyphenyl)oxazolo[4,5-b]pyridin-2-amine
• 英文别名: N-(4-methoxyphenyl)-[1,3]oxazolo[4,5-b]pyridin-2-amine
• CAS: 1564283-79-9
• 化学式: C₁₃H₁₁N₃O₂
• 分子量: 241.249
• InChiKey: IDGSSNCHBITMBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-3-羟基吡啶 、 4-甲氧基苯基 异硫氰酸酯 在 copper(l) iodide 、 三乙胺 作用下， 以 水 为溶剂， 100.0 ℃ 、172.37 kPa 条件下， 反应 0.08h， 以81%的产率得到N-(4-methoxyphenyl)oxazolo[4,5-b]pyridin-2-amine
  参考文献：
  名称：

  Microwave assisted synthesis of 2-aminooxazolo [4,5-b] pyridine derivatives via intramolecular C–O bond formation in aqueous medium

  摘要：

  A highly, efficient synthetic protocol for the synthesis of 2-aminooxazolo[4,5-b]pyridine derivatives is established via intramolecular C-O bond coupling using copper iodide as a catalyst and water as solvent. A variety of functionalized substrates were found to react under this reaction conditions to provide products in good to excellent yields. (C) 2014 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/3.0/).

  DOI：

  10.1016/j.tetlet.2013.12.090

文献信息

• Microwave assisted synthesis of 2-aminooxazolo [4,5-b] pyridine derivatives via intramolecular C–O bond formation in aqueous medium
  作者：Umesh B. Kosurkar、Tulshiram L. Dadmal、K. Appalanaidu、Y. Khageswara Rao、Jagadeesh B. Nanubolu、Ravindra M. Kumbhare

  DOI：10.1016/j.tetlet.2013.12.090

  日期：2014.2

  A highly, efficient synthetic protocol for the synthesis of 2-aminooxazolo[4,5-b]pyridine derivatives is established via intramolecular C-O bond coupling using copper iodide as a catalyst and water as solvent. A variety of functionalized substrates were found to react under this reaction conditions to provide products in good to excellent yields. (C) 2014 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/3.0/).