N-(2,2,6,6-tetramethyl-4-piperidyl)-N'-(2-amino-2-methylpropyl)-1,2-ethanediamine | 123762-19-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(2,2,6,6-tetramethyl-4-piperidyl)-N'-(2-amino-2-methylpropyl)-1,2-ethanediamine
• 英文别名: 2-methyl-1-N-[2-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]ethyl]propane-1,2-diamine
• CAS: 123762-19-6
• 化学式: C₁₅H₃₄N₄
• 分子量: 270.462
• InChiKey: ILKKFXKMZZFWEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.1
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Alkylated polyalkylene polyamines and process for selective alkylation
  申请人：THE B.F. GOODRICH COMPANY

  公开号：EP0309980A1

  公开（公告）日：1989-04-05

  A branched chain polyalkylene polyamine ("PAPA") having plural amine groups, including a secondary amine group intermediate terminal primary amine groups one of which is hindered, and having at least two carbon atoms between each group, is selectively reductively alkylated with a ketone. The reaction provides a convenient method for selectively reductively alkylating a PAPA having a hindered primary amine group, the method comprising cont­acting the PAPA with hydrogen and the ketone in the pre­sence of a catalytically effective amount of a Group VIII metal on a catalyst support, at a pressure in the range from about 100-1000 psi and a temperature in the range from about 50°C to about 200°C for a period of time suffi­cient to preferentially alkylate the unhindered amine primary terminal amine group. The alkylation proceeds essentially without alkylating either the sterically hind­ered terminal primary amine group or the intermediate unhindered secondary amine group. Cross-Reference to Related Applications: This application is a continuation-in-part of Ser. No. 786,765 filed October 11, 1985, which in turn is a continuation-in-part of Ser. No. 664,901 filed October 26, 1984, now issued as U.S. Patent No. 4,547,538 which is in turn a continuation-­in-part application of Ser. No. 350,536 filed February 2, 1982 now issued as U.S. Patent No. 4,480,092.

  一种支链聚亚烷基多胺（"PAPA"）具有多个胺基团，包括一个仲胺基团中间的末端伯胺基团，其中一个是受阻胺基团，每个基团之间至少有两个碳原子，用酮选择性地还原烷基化。该反应提供了一种选择性还原烷基化具有受阻伯胺基团的 PAPA 的简便方法，该方法包括在催化剂载体上催化有效量的 VIII 族金属存在下，在约 100-1000 psi 的压力和约 50°C 至约 200°C 的温度范围内，使 PAPA 与氢和酮接触，接触时间足以优先烷基化未受阻胺伯端胺基团。烷基化过程基本上不会烷基化立体受阻的末端伯胺基团或中间无阻仲胺基团。 与相关申请的对照检索：本申请是 1985 年 10 月 11 日提交的第 786,765 号系列申请的部分延续，而第 786,765 号系列申请又是 1984 年 10 月 26 日提交的第 664,901 号系列申请的部分延续，现已作为第 4,547,538 号美国专利颁发，而第 664,901 号系列申请又是 1982 年 2 月 2 日提交的第 350,536 号系列申请的部分延续，现已作为第 4,480,092 号美国专利颁发。
• US5189173A
  申请人：——

  公开号：US5189173A

  公开（公告）日：1993-02-23
• US5270471A
  申请人：——

  公开号：US5270471A

  公开（公告）日：1993-12-14