N-[[(2R,3R,4R,5R)-1-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]methyl]acetamide | 909403-79-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-[[(2R,3R,4R,5R)-1-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]methyl]acetamide
• CAS: 909403-79-8
• 化学式: C₁₄H₂₉N₃O₆
• 分子量: 335.401
• InChiKey: KBMJEEIAYHPBDW-AAVRWANBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  23
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  138
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Novel Five-Membered Iminocyclitol Derivatives as Selective and Potent Glycosidase Inhibitors: New Structures for Antivirals and Osteoarthritis Therapeutics
  申请人：Liang Pi-Hui

  公开号：US20090306174A1

  公开（公告）日：2009-12-10

  Novel 5-membered iminocyclitol derivatives were found to be a potent and selective inhibitors of the glycoprotein processing α- and β-glucosidase which were further found to be active antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus and human β-hexosaminidase, a new target for development of osteoarthritis therapeutics.