5-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-1H-indazole-3-carbonitrile | 1301216-41-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 5-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-1H-indazole-3-carbonitrile
• 英文别名: 5-(7-oxo-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-1'-carbonyl)-1H-indazole-3-carbonitrile
• CAS: 1301216-41-0
• 化学式: C₂₃H₂₄N₆O₂
• 分子量: 416.483
• InChiKey: QMTXJSFTABXSSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] USE OF ACETYL-COA CARBOXYLASE INHIBITORS FOR TREATING ACNE VULGARIS<br/>[FR] UTILISATION D'INHIBITEURS DE L'ACÉTYL-COA CARBOXYLASE POUR TRAITER L'ACNÉ VULGAIRE
  申请人：PFIZER

  公开号：WO2015036892A1

  公开（公告）日：2015-03-19

  The present invention relates to methods of treating and/or preventing acne in patients comprising the step of administering to patients in need of such treatment a therapeutically effective amount of an ACC inhibitor or a pharmaceutically acceptable salt thereof.

  本发明涉及治疗和/或预防痤疮的方法，包括向需要此类治疗的患者施用治疗有效量的ACC抑制剂或其药用盐。
• N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors
  申请人：Pfizer Inc.

  公开号：US20130030181A1

  公开（公告）日：2013-01-31

  The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R 1 , R 2 , R 3 and R 4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

  本发明提供了一种公式(I)的化合物或其药学上可接受的盐，其中R1、R2、R3和R4如本文所述；其制备的药物组合物；以及将其用于治疗受到动物中乙酰辅酶A羧化酶酶抑制调节的疾病、病况或障碍。
• USE OF ACETYL-COA CARBOXYLASE INHIBITORS FOR TREATING ACNE VULGARIS
  申请人：PFIZER INC.

  公开号：US20160220557A1

  公开（公告）日：2016-08-04

  The present invention relates to methods of treating and/or preventing acne in patients comprising the step of administering to patients in need of such treatment a therapeutically effective amount of an ACC inhibitor or a pharmaceutically acceptable salt thereof.

  本发明涉及一种治疗和/或预防痤疮的方法，包括向需要此类治疗的患者施用治疗有效量的ACC抑制剂或其药学上可接受的盐。
• US8507681B2
  申请人：——

  公开号：US8507681B2

  公开（公告）日：2013-08-13