(5R,7S)-8-[(2'-ethylbiphenyl-3-yl)methyl]-1-(3-fluorophenyl)-7-methyl-2-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide | 1193782-65-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (5R,7S)-8-[(2'-ethylbiphenyl-3-yl)methyl]-1-(3-fluorophenyl)-7-methyl-2-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
• 英文别名: (5R,7S)-8-[[3-(2-ethylphenyl)phenyl]methyl]-1-(3-fluorophenyl)-7-methyl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide；(5R,7S)-8-[[3-(2-ethylphenyl)phenyl]methyl]-1-(3-fluorophenyl)-7-methyl-2λ6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide
• CAS: 1193782-65-8
• 化学式: C₂₈H₃₂FN₃O₂S
• 分子量: 493.645
• InChiKey: DFEKPRLLWWWLDM-RBTNQOKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] NOVEL CLASS OF SPIRO PIPERIDINES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES<br/>[FR] NOUVELLE CLASSE DE SPIRO PIPÉRIDINES POUR LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：PFIZER

  公开号：WO2009136350A1

  公开（公告）日：2009-11-12

  Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  本发明揭示了化合物及其在规范中定义的结构为化学式（I）的药用可接受盐。同时还揭示了相应的药用组合物、治疗方法、合成方法和中间体。
• Novel Class of Spiro Piperidines for the Treatment of Neurodegenerative Diseases
  申请人：Brodney Michael A.

  公开号：US20110046160A1

  公开（公告）日：2011-02-24

  Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  本发明公开了化合物及其药用可接受盐，其中该化合物具有规范中定义的公式（I）的结构。同时还公开了相应的药物组合物、治疗方法、合成方法和中间体。
• NOVEL CLASS OF SPIRO PIPERIDINES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：Pfizer Inc.

  公开号：EP2300484A1

  公开（公告）日：2011-03-30