(2S,5R)-5-(2-chlorophenyl)-1-(4-(6-fluoropyridin-3-yl)benzoyl)pyrrolidine-2-carboxylic acid | 1312800-67-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (2S,5R)-5-(2-chlorophenyl)-1-(4-(6-fluoropyridin-3-yl)benzoyl)pyrrolidine-2-carboxylic acid
• 英文别名: (2S,5R)-5-(2-chlorophenyl)-1-[4-(6-fluoropyridin-3-yl)benzoyl]pyrrolidine-2-carboxylic acid
• CAS: 1312800-67-1
• 化学式: C₂₃H₁₈ClFN₂O₃
• 分子量: 424.859
• InChiKey: BYNTXZQOYLQXPP-UXHICEINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  70.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE TRIAZOLINETHIONES ET INTERMÉDIAIRES DE CES COMPOSÉS
  申请人：BASF SE

  公开号：WO2011073145A1

  公开（公告）日：2011-06-23

  The present invention relates to a new process for the preparation of substituted thio-triazolo groups of the general formula (I) wherein the variables have the meanings as given in the claims and the description.

  本发明涉及一种新的制备取代硫代三唑基团的方法，其化学式为(I)，其中变量的含义如权利要求书和说明中所述。
• PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS AS AGONISTS OF G-PROTEIN COUPLED RECEPTOR 43 (GPR43)
  申请人：Hoveyda Hamid R.

  公开号：US20130023539A1

  公开（公告）日：2013-01-24

  The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.

  本发明涉及式（I）的新化合物及其在治疗和/或预防代谢性疾病方面的应用。
• COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING INFLAMMATORY DISEASES
  申请人：EPICS THERAPEUTICS

  公开号：EP3610872A1

  公开（公告）日：2020-02-19

  The present invention is directed to compounds of formula I useful in treating and/or preventing inflammatory diseases.

  本发明涉及式 I 的化合物 用于治疗和/或预防炎症性疾病。
• Substituted pyrrolidines as G-protein coupled receptor 43 agonists
  申请人：Ogeda SA

  公开号：US10017468B2

  公开（公告）日：2018-07-10

  The present invention is directed to a process for the preparation of aryl-pyrrolidine carboxylic acid derivative compounds which are useful in treating metabolic diseases, said process consisting of coupling an aryl-pyrrolidine compound with an aryl carboxylic acid compound followed by alkaline or acidic treatment, hydrogenolysis or treatment with a fluoride of the ester intermediate to afford novel aryl-pyrrolidine carboxylic acid derivative compounds.

  本发明涉及一种用于制备治疗代谢性疾病的芳基吡咯烷羧酸衍生物化合物的工艺，所述工艺包括将芳基吡咯烷化合物与芳基羧酸化合物偶联，然后对酯类中间体进行碱性或酸性处理、氢解或用氟化物处理，以得到新型芳基吡咯烷羧酸衍生物化合物。
• Pyrrolidine carboxylic acid derivatives as agonists of G-protein coupled receptor 43 (GPR43), pharmaceutical composition and methods for use in treating metabolic disorders
  申请人：OGEDA SA

  公开号：EP2513053B1

  公开（公告）日：2017-10-04