1-[5-(2,5-Difluorophenyl)spiro[1,3,4-oxadiazole-2,4'-2,3-dihydrothiochromene]-3-yl]ethanone | 1151482-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫平类
• 英文名称: 1-[5-(2,5-Difluorophenyl)spiro[1,3,4-oxadiazole-2,4'-2,3-dihydrothiochromene]-3-yl]ethanone
• CAS: 1151482-43-7
• 化学式: C₁₈H₁₄F₂N₂O₂S
• 分子量: 360.384
• InChiKey: VQUIXPGUUBYAOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  67.2
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY<br/>[FR] COMPOSÉS POUR INHIBER L'ACTIVITÉ DE LA KINÉSINE KSP
  申请人：SCHERING CORP

  公开号：WO2009061595A1

  公开（公告）日：2009-05-14

  The present invention relates to compounds of Formula (I), below, (wherein R1, R2, R3, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity.

  本发明涉及以下式（I）的化合物（其中R1、R2、R3、p、E、环A和环B的定义如本文所述）。本发明还涉及包括这些化合物的组合物（包括药用合成物），单独或与一个或多个额外治疗剂结合使用的方法，以及用于抑制KSP动力蛋白活性和治疗与KSP动力蛋白活性相关的细胞增殖性疾病或紊乱的方法。
• COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY
  申请人：Siddiqui M. Arshad

  公开号：US20110171172A1

  公开（公告）日：2011-07-14

  The present invention relates to compounds of Formula (I), below, (wherein R 1 , R 2 , R 3 , p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity.