cis-diamminedichloroplatinum(II)-d6 | 13933-19-2

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属盐
• 英文名称: cis-diamminedichloroplatinum(II)-d6
• 英文别名: cis-PtCl2(ND3)2
• CAS: 13933-19-2；52260-83-0
• 化学式: Cl₂H₆N₂Pt
• 分子量: 305.999
• InChiKey: LXZZYRPGZAFOLE-YIKVAAQNSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  重水 、 cisplatin 在 sodium chloride 作用下， 以 重水 为溶剂， 生成 cis-diamminedichloroplatinum(II)-d6
  参考文献：
  名称：

  Molecular Architecture of Nanocapsules, Bilayer-Enclosed Solid Particles of Cisplatin

  摘要：

  Cisplatin nanocapsules represent a lipid formulation of the anticancer drug cis-diamminedichlo-roplatinum(II) (cisplatin) characterized by an unprecedented cisplatin-to-lipid ratio and exhibiting strongly improved cytotoxicity against tumor cells in vitro as compared to the free drug (Burger, K. N. J., et al. Nat. Med. 2002, 8, 81-84). Cisplatin nanocapsules are prepared by the repeated freezing and thawing of an equimolar dispersion of phosphatidylserine (PS) and phosphatidylcholine (PC) in a concentrated aqueous solution of cisplatin. Here, the molecular architecture of these novel nanostructures was elucidated by solid-state NMR techniques. N-15 NMR and H-2 NMR spectra of nanocapsules containing N-15- and H-2-labeled cisplatin, respectively, demonstrated that the core of the nanocapsules consists of solid cisplatin devoid of free water. Magic-angle spinning N-15 NMR showed that similar to90% of the cisplatin in the core is present as the dichloro species. The remaining 10% was accounted for by a newly discovered dinuclear Pt compound that was identified as the positively charged chloride-bridged dimer of cisplatin. NMR techniques sensitive to lipid organization, P-31 NMR and H-2 NMR, revealed that the cisplatin core is coated by phospholipids in a bilayer configuration and that the interaction between solid core and bilayer coat exerts a strong ordering effect on the phospholipid molecules. Compared to phospholipids in liposomal membranes, the motion of the phospholipid headgroups is restricted and the ordering of the acyl chains is increased, particularly in PS. The implications of these findings for the structural organization, the mechanism of formation, and the mode of action of cisplatin nanocapsules are discussed.

  DOI：

  10.1021/ja0468933

文献信息

• The hydrolysis products of cis-diamminedichloroplatinum(II) 7. The rate of the hydrogen isotope exchange reaction
  作者：Edward Koubek、Donald A. House

  DOI：10.1016/s0020-1693(00)80335-7

  日期：1992.1

  The rate of the N-H --> N-D exchange reaction for cis-PtCl2(NH3)2, PtCl2(en) and PtCl2(tn) has been measured in succinate buffered D2O. Samples of the complex were precipitated as the HgCl2 adduct, at various times, and the extent of deuteration was estimated by IR spectroscopy. The rate of the reaction is proportional to the [OD-] and activation parameters for the three complexes (I = 0.1 M NaCl, 25.0-degrees-C) in the order (NH3)2, (en), (tn) are: 10(4) k(ex) (M-1 s-1) = 135, 51.4, 3.64; DELTA-H not-equal (kJ mol-1) and 24.9, 21.2, 50.0; DELTA-S not-equal (J K-1 mol-1) = -44.1, -64.6, + 10.2.