N,N'-Bis-[4-(trityl-amino)-butyl]-N,N'-bis-[3-(trityl-amino)-propyl]-succinamide | 244033-14-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N,N'-Bis-[4-(trityl-amino)-butyl]-N,N'-bis-[3-(trityl-amino)-propyl]-succinamide
• CAS: 244033-14-5
• 化学式: C₉₄H₉₆N₆O₂
• 分子量: 1341.84
• InChiKey: PRUKMRYQLOMYEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  18.09
• 重原子数：
  102.0
• 可旋转键数：
  37.0
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  88.74
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  N,N'-Bis-[4-(trityl-amino)-butyl]-N,N'-bis-[3-(trityl-amino)-propyl]-succinamide 在 盐酸 作用下， 生成 N,N'-Bis-(4-amino-butyl)-N,N'-bis-(3-amino-propyl)-succinamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT
  参考文献：
  名称：

  Synthesis of spermidine and norspermidine dimers as high affinity polyamine transport inhibitors

  摘要：

  A series of novel spermidine and sym-norspermidine dimers was synthesized by crosslinking the polyamine backbones via alkylation of their secondary amino groups to butyl, trans-2-butenyl, 2-butynyl or p-xylyl bridges. The resulting hexamines behaved as high-affinity antagonists of polyamine uptake, with a relative potency that was dependent on the geometry of the linker structure. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00262-0
• 作为产物：
  描述：

  丁二酰氯 、 N¹,N⁸-ditritylspermidine 在 三乙胺 作用下， 以 氯仿 为溶剂， 生成 N,N'-Bis-[4-(trityl-amino)-butyl]-N,N'-bis-[3-(trityl-amino)-propyl]-succinamide
  参考文献：
  名称：

  Synthesis of spermidine and norspermidine dimers as high affinity polyamine transport inhibitors

  摘要：

  A series of novel spermidine and sym-norspermidine dimers was synthesized by crosslinking the polyamine backbones via alkylation of their secondary amino groups to butyl, trans-2-butenyl, 2-butynyl or p-xylyl bridges. The resulting hexamines behaved as high-affinity antagonists of polyamine uptake, with a relative potency that was dependent on the geometry of the linker structure. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00262-0