3-氰基哌啶盐酸盐 | 1199773-75-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 3-氰基哌啶盐酸盐
• 英文名称: piperidine-3-carbonitrile hydrochloride
• 英文别名: piperidine-3-carbonitrile;hydrochloride
• CAS: 1199773-75-5
• 化学式: C₆H₁₀N₂*ClH
• 分子量: 146.62
• InChiKey: UGNVDGLCOHDISF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.93
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  35.8
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P305+P351+P338
• 危险性描述：
  H302,H319

反应信息

• 作为产物：
  描述：

  1-Boc-3-氰基哌啶 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 以48%的产率得到3-氰基哌啶盐酸盐
  参考文献：
  名称：

  Carbazole inhibitors of histamine receptors for the treatment of disease

  摘要：

  本发明涉及咔唑化合物，包括它们的药物组合物，以及可能作为H1R和/或H4R的抑制剂用于治疗或预防炎症性、自身免疫性、过敏性和眼部疾病的方法。

  公开号：

  US08080566B1

文献信息

• SUBSTITUTED PYRAZOLO[3,4-b]PYRIDIN-6-CARBOXYLIC ACIDS AND METHOD OF USE
  申请人：AbbVie S.à.r.l.

  公开号：US20170101406A1

  公开（公告）日：2017-04-13

  The present invention provides for compounds of formula (I) wherein R 1 , R 2 , R 3 , and R 4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

  本发明提供了式（I）的化合物 其中R 1 ，R 2 ，R 3 和R 4 具有规范中定义的任何值，以及其药学上可接受的盐，这些化合物在治疗由CFTR介导和调节的疾病和症状中是有用的，包括囊性纤维化、Sjögren综合征、胰腺功能不全、慢性阻塞性肺病和慢性阻塞性气道疾病。还提供了由一个或多个式（I）的化合物组成的药物组合物。
• Substituted Oxadiazole Derivatives as Positive Allosteric Modulators of Metabotropic Glutamate Receptors
  申请人：Farina Marco

  公开号：US20090215822A1

  公开（公告）日：2009-08-27

  The present invention relates to new compounds which are Oxadiazole derivatives of formula (I) wherein B, P, Q, W, R 1 and R 2 are defined in the description. Invention compounds are useful in the prevention or treatment of central or peripheral nervous system disorders as well as other disorders modulated by mGluR5 receptors.(I).

  本发明涉及一种新化合物，其为式(I)的噁二唑衍生物，其中B、P、Q、W、R1和R2在描述中有定义。该发明化合物在预防或治疗中枢或外周神经系统疾病以及其他受mGluR5受体调节的疾病方面具有用途。(I)。
• Novel Heterocyclic Compounds as Positive Allosteric Modulators of Metabotropic Glutamate Receptors
  申请人：Farina Marco

  公开号：US20100004284A1

  公开（公告）日：2010-01-07

  The present invention relates to new compounds which are Heterocyclic derivatives of formula (I) wherein A, B, P, X, Y, Q, W, R 1 and R 2 are defined in the description. Invention compounds are useful for treating central or peripheral nervous system disorders and other disorders which are affected by the neuromodulatory effect of mGluR5 positive allosteric modulators such as cognitive decline and also to treat both positive and negative symptoms in schizophrenia.

  本发明涉及公式（I）的新化合物，其为杂环衍生物，其中A，B，P，X，Y，Q，W，R1和R2在说明书中定义。发明化合物可用于治疗中枢或外周神经系统疾病以及其他受mGluR5阳性变构调节剂神经调节作用影响的疾病，如认知衰退，并可用于治疗精神分裂症的阳性和阴性症状。
• Pyrrole Derivatives as Positive Allosteric Modulators of Metabotropic Receptors
  申请人：Gagliardi Stefania

  公开号：US20090203737A1

  公开（公告）日：2009-08-13

  The present invention relates to new compounds which are Pyrrole derivatives of formula (I) wherein A, B, P, Q 5 W, R 1 and R 2 are defined in the description. Invention compounds are useful in the prevention or treatment of central or peripheral nervous system disorders as well as other disorders modulated by mGluR5 receptors.

  本发明涉及新的化合物，它们是公式（I）的吡咯衍生物，其中A、B、P、Q5W、R1和R2在说明中有定义。发明化合物在预防或治疗中枢或外周神经系统疾病以及其他受mGluR5受体调节的疾病方面很有用。
• NITROGEN-CONTAINING HETEROCYLIC COMPOUND OR SALT THEREOF
  申请人：FUJIFILM Corporation

  公开号：EP2944637A1

  公开（公告）日：2015-11-18

  A compound represented by Formula [1] (in the formula, Z1 represents N, CH, or the like; X1 represents NH or the like; R1 represents a heteroaryl group or the like; each of R2, R3, and R4 represents a hydrogen atom, a halogen atom, an alkoxy group, or the like; and R5 represents a heteroaryl group or the like) or salt thereof.

  式 [1] 所代表的化合物（式中，Z1 代表 N、CH 或类似物；X1 代表 NH 或类似物；R1 代表杂芳基或类似物；R2、R3 和 R4 各代表氢原子、卤素原子、烷氧基或类似物；R5 代表杂芳基或类似物）或其盐。