(2-(Diethylamino)ethy]-9-methoxy-2H-[1]-benzothiopyrano[4,3,2-cd]indazole-5-methanamine | 179632-37-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫色烯
• 英文名称: (2-(Diethylamino)ethy]-9-methoxy-2H-[1]-benzothiopyrano[4,3,2-cd]indazole-5-methanamine
• 英文别名: 2-[10-(aminomethyl)-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-14-yl]-N,N-diethylethanamine
• CAS: 179632-37-2
• 化学式: C₂₁H₂₆N₄OS
• 分子量: 382.53
• InChiKey: LXPWDZUBGNMLPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  81.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2-(Diethylamino)ethy]-9-methoxy-2H-[1]-benzothiopyrano[4,3,2-cd]indazole-5-methanamine 在 三溴化硼 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 methyl N-[[14-[2-(diethylamino)ethyl]-4-hydroxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methyl]carbamate
  参考文献：
  名称：

  Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives

  摘要：

  Two new series of antitumor agents, 4-aminomethylthioxanthenones (6-50) and 5-aminomethylbenzothiopyranoindazoles (51-61), are described and compared. Nearly all members of both series display excellent in vivo activity versus murine pancreatic adenocarcinoma 03 (Panc03) although there is little to distinguish the two series from each other. In both series there is no discernible relationship between structure and in vivo efficacy. Selected analogues were evaluated in vitro; all were observed to have moderate to strong DNA binding via intercalation. However, varying degrees of in vitro P388 cytotoxicity and topoisomerase II inhibition were seen. In general, those molecules which exhibited strong topoisomerase II inhibition were significantly more cytotoxic than those which did not. In both series, those derivatives (48-50, 60, and 61) having a phenolic hydroxy substitution exhibited the most potent P388 cytotoxicity and topoisomerase II inhibition.

  DOI：

  10.1021/jm9708083
• 作为产物：
  描述：

  N-[2-(diethylamino)ethyl]hydrazine 在 sodium hydroxide 、 3-Cl-C₁₃H₆SO(OCH₃) 、 三氯氧磷 作用下， 以 吡啶 、 甲醇 、 甲酸 、 水 为溶剂， 生成 (2-(Diethylamino)ethy]-9-methoxy-2H-[1]-benzothiopyrano[4,3,2-cd]indazole-5-methanamine
  参考文献：
  名称：

  Cyclic variations of SR 233377 (WIN 33377) and effects on antitumor activity

  摘要：

  Novel derivatives of SR 233377 (1, WIN 33377) where a pyrazolo ring fusion has been incorporated at the 1- and 9-positions of the thioxanthone ring displayed outstanding in vivo efficacy against the murine solid tumor Pane 03 (T/C values of 0% with log cell kill greater than or equal to 2.0). No relationship between structure and Pane 03 activity was observed because all analogues studied were highly active. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00230-2

文献信息

• Benzothiopyranoindazole antitumor agents
  申请人：Sterling Winthrop Inc.

  公开号：US05532263A1

  公开（公告）日：1996-07-02

  Novel 2H-[1]benzothiopyrano[4,3,2-cd]indazoles are disclosed as antitumor agents. Compositions containing the benzothiopyranoindazoles and methods of treating tumors and cancer in mammals with benzothiopyranoindazoles are also disclosed.

  本发明公开了2H-[1]苯并硫杂吡喃并[4,3,2-cd]吲哚类化合物作为抗肿瘤药物。同时还公开了含有苯并硫杂吡喃并吲哚类化合物的组合物以及使用苯并硫杂吡喃并吲哚类化合物治疗哺乳动物的肿瘤和癌症的方法。
• Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives
  作者：Robert B. Perni、Mark P. Wentland、Jianhua I. Huang、Ronald G. Powles、Suzanne Aldous、Kristina M. Klingbeil、A. Danielle Peverly、Ronald G. Robinson、Thomas H. Corbett、Julie L. Jones、Kenneth C. Mattes、James B. Rake、Susan A. Coughlin

  DOI：10.1021/jm9708083

  日期：1998.9.1

  Two new series of antitumor agents, 4-aminomethylthioxanthenones (6-50) and 5-aminomethylbenzothiopyranoindazoles (51-61), are described and compared. Nearly all members of both series display excellent in vivo activity versus murine pancreatic adenocarcinoma 03 (Panc03) although there is little to distinguish the two series from each other. In both series there is no discernible relationship between structure and in vivo efficacy. Selected analogues were evaluated in vitro; all were observed to have moderate to strong DNA binding via intercalation. However, varying degrees of in vitro P388 cytotoxicity and topoisomerase II inhibition were seen. In general, those molecules which exhibited strong topoisomerase II inhibition were significantly more cytotoxic than those which did not. In both series, those derivatives (48-50, 60, and 61) having a phenolic hydroxy substitution exhibited the most potent P388 cytotoxicity and topoisomerase II inhibition.
• Cyclic variations of SR 233377 (WIN 33377) and effects on antitumor activity
  作者：Mark P. Wentland、Robert B. Perni、Jianhua I. Huang、Ronald G. Powles、Suzanne C. Aldous、Kristina M. Klingbeil、A. Danielle Peverly、Ronald G. Robinson、Thomas H. Corbett、Julie L. Jones、James B. Rake、Susan A. Coughlin

  DOI：10.1016/0960-894x(96)00230-2

  日期：1996.6

  Novel derivatives of SR 233377 (1, WIN 33377) where a pyrazolo ring fusion has been incorporated at the 1- and 9-positions of the thioxanthone ring displayed outstanding in vivo efficacy against the murine solid tumor Pane 03 (T/C values of 0% with log cell kill greater than or equal to 2.0). No relationship between structure and Pane 03 activity was observed because all analogues studied were highly active. Copyright (C) 1996 Elsevier Science Ltd