1-Methyl-4-[(methylamino)methyl]piperidin-4-ol | 116250-52-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Methyl-4-[(methylamino)methyl]piperidin-4-ol
• 英文别名: 1-methyl-4-(methylaminomethyl)piperidin-4-ol
• CAS: 116250-52-3
• 化学式: C₈H₁₈N₂O
• mdl: MFCD11580067
• 分子量: 158.24
• InChiKey: YUQFKXYKVOBONS-UHFFFAOYSA-N

物化性质

• 沸点：
  252.0±15.0 °C(Predicted)
• 密度：
  0.993±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• SUBSTITUTED 4-PYRIDONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
  申请人：OOST Thorsten

  公开号：US20140057916A1

  公开（公告）日：2014-02-27

  This invention relates to substituted 4-pyridones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other auto-immune and allergic disorders, allograft rejection, and oncological diseases.

  这项发明涉及式1的取代4-吡啶酮及其作为中性粒细胞弹性蛋白酶活性抑制剂的用途，包含这些化合物的药物组合物，以及将其用作治疗和/或预防肺部、胃肠道和泌尿系统疾病、皮肤和眼睛的炎症性疾病以及其他自身免疫和过敏性疾病、移植物排斥反应和肿瘤性疾病的药剂的方法。
• NITROGEN-CONTAINING FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

  公开号：EP3929185A1

  公开（公告）日：2021-12-29

  The present invention relates to a nitrogen-containing fused ring compound, a preparation method and use thereof. Specifically, the present invention relates to a compound having the structure of Formula (X), a stereoisomer, tautomer or mixture thereof, a pharmaceutically acceptable salt, co-crystal, polymorph or solvate thereof, or a stable isotope derivative, metabolite or prodrug thereof. The compound of the invention may have the structure of Formula (I) or Formula (II). These compounds are useful for the treatment of an abnormal cell proliferation disease (e.g., cancer).         R-L-R3     (X)

  本发明涉及一种含氮融合环化合物，其制备方法和用途。具体而言，本发明涉及具有化学式（X）结构的化合物，其立体异构体、互变异构体或它们的混合物，药学上可接受的盐、共晶体、多型体或溶剂合物，或其稳定同位素衍生物、代谢物或前药。本发明的化合物可能具有化学式（I）或化学式（II）的结构。这些化合物对于治疗异常细胞增殖疾病（例如癌症）是有用的。 R-L-R3（X）
• MORPHOLINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS
  申请人：Hadida-Ruah Sara Sabina

  公开号：US20120264749A1

  公开（公告）日：2012-10-18

  The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及一种用于离子通道抑制剂的吗啡啶螺环哌啶酰胺化合物。本发明还提供了包含该化合物的药学上可接受的组合物，并提供了使用该组合物治疗各种疾病的方法。
• TETRACYCLIC INHIBITORS OF JANUS KINASES
  申请人：Rodgers James D.

  公开号：US20090215766A1

  公开（公告）日：2009-08-27

  The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.

  本发明提供了一种可以调节Janus激酶活性的化合物，这些化合物可用于治疗与Janus激酶活性相关的疾病，例如免疫相关疾病和癌症。
• Aromatic-Spiropiperidine oxazepinones (and thiones)
  申请人：A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation)

  公开号：EP0295833A1

  公开（公告）日：1988-12-21

  Novel aromatic-spiropiperidineoxazepinones and thiones exhibiting antihistamine activity are disclosed having the formula: wherein A represents an aromatic ring, selected from benzo when Z is carbon or pyrido[3,2-f] when Z is nitrogen either of which rings may be optionally substituted on carbon;     B is selected from oxygen or sulfur;     R¹ is selected from the group consisting of loweralkyl, cycloalkyl, cycloalkyl-loweralkyl or phenyl-loweralkyl of which phenyl may be optionally substituted;     R is selected from the group consisting of loweralkyl, cycloalkyl or phenyl-loweralkyl of which phenyl may be optionally substituted and the pharmaceutically acceptable salts thereof and novel chemical intermediates in the preparation thereof.

  本发明公开了具有抗组胺活性的新型芳香-硫代哌啶氧氮杂环庚酮和硫酮，其式如下 其中 A 代表芳香环，当 Z 为碳时，选自苯并环，当 Z 为氮时，选自吡啶并[3,2-f]环； B 选自氧或硫； R¹ 选自低烷基、环烷基、环烷基-低烷基或苯基-低烷基组成的组，其中苯基可被任选取代； R¹选自低级烷基、环烷基或苯基-低级烷基（其中苯基可被任选取代）组成的组，以及它们的药学上可接受的盐和制备它们的新型化学中间体。