5-(2-hydroxy-ethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium; [4-(4-dimethylamino-phenylazo)-benzenesulfonate ] | 123965-06-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: 5-(2-hydroxy-ethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium; [4-(4-dimethylamino-phenylazo)-benzenesulfonate ]
• 英文别名: 5-(2-Hydroxy-aethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium; [4-(4-Dimethylamino-phenylazo)-benzolsulfonat]
• CAS: 123965-06-0
• 化学式: C₁₂H₁₆N₃O₂S*C₁₄H₁₄N₃O₃S
• 分子量: 570.693
• InChiKey: WGGCUEXGZKFMCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.39
• 重原子数：
  39.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  155.02
• 氢给体数：
  2.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  5-(2-hydroxy-ethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium; [4-(4-dimethylamino-phenylazo)-benzenesulfonate ] 、 alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 生成 N-[(Z)-3-[[(Z)-2-[formyl-[(2-methyl-6-oxo-1H-pyrimidin-5-yl)methyl]amino]-5-hydroxypent-2-en-3-yl]disulfanyl]-5-hydroxypent-2-en-2-yl]-N-[(2-methyl-6-oxo-1H-pyrimidin-5-yl)methyl]formamide
  参考文献：
  名称：

  铁氰化钾氧化硫胺素及其类似物

  摘要：

  DOI：

  10.1039/jr9540004585
• 作为产物：
  描述：

  5-(氨基甲基)-2-甲基-4(1H)-嘧啶酮 在 盐酸 、 水 、 氢溴酸 、 溶剂黄146 、 sodium nitrite 作用下， 生成 5-(2-hydroxy-ethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium; [4-(4-dimethylamino-phenylazo)-benzenesulfonate ]
  参考文献：
  名称：

  Use of Muscle Functional Magnetic Resonance Imaging With Older Individuals

  摘要：

  Muscle functional magnetic resonance imaging (mfMRI) has been widely used to study muscle recruitment in exercise in young healthy subjects, but has not been validated or used with older subjects. This study validates and demonstrates the use of mfMRI in older subjects. Subjects consisted of apparently healthy sedentary younger (n = 7) and older (n = 6) women. Proton transverse relaxation (T2)-weighted MRI scans were obtained of the quadriceps femoris at rest and immediately following three bouts of knee extension exercise (50%, 75%, and 100% of untrained 5 x 10 repetition maximum [RM]). Older subjects performed knee extension training for 12 weeks and repeated the MRI scan protocol using the same absolute loads. Training induced a 13% increase in 1 RM and a 25% increase in 5 x 10 RM. Older subjects had higher resting T2 values compared with younger subjects; however, the T2 response to exercise (slope) was similar among groups (young = 0.063 +/- 0.003, older untrained = 0.055 +/- 0.011, older trained = 0.053 +/- 0.008; p > .05). In all cases, T2 increased Linearly with load. Trained older subjects showed a lower T2 response when lifting the same absolute load compared with before training, which is consistent with results previously obtained from young subjects. In the older population, mfMRI is appropriate for use and offers benefits over other technologies.

  DOI：

  10.1093/gerona/55.10.b504

文献信息

• Does Age Change the Distribution of Visual Attention? A Comment on McCalley, Bouwhuis, and Juola (1995)
  作者：F. W. Cornelissen、A. C. Kooijman

  DOI：10.1093/geronb/55.3.p187

  日期：2000.5.1

  A paper, by McCalley, Bouwhuis, and Juola (1995) suggested differences between younger and older adults in the use of visual cues. Furthermore, they reported these differences could largely be attributed to diminished (peripheral al) visual proressing capacities of elderly adults. I-It re, we reanalyze the data of McCalley and colleagues emphasizing relative rather than absolute differences. We find that when doing so, the data do not reveal differences in the way older and younger adults transiently allocate attention during visual search. Contrary to the conclusions of McCalley and colleagues, the similarity between the younger and older observers is therefore independent of the characteristics of the visual information. Furthermore, in our view the data suggest that older adults have foveal rather than peripheral visual processing difficulties. The results reemphasize the importance of the analytical approach taken in aging research, We discuss the difficulties and relevance of controlling and separating visual and attentional factors in age-related studies.
• Matsukawa; Yurugi, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1951, vol. 71, p. 827
  作者：Matsukawa、Yurugi

  DOI：——

  日期：——
• 310. Aneurin. Part VIII. Some analogues of aneurin
  作者：F. Bergel、A. R. Todd

  DOI：10.1039/jr9370001504

  日期：——
• Note on an improved method for the preparation of oxythiamine
  作者：H. N. Rydon

  DOI：10.1042/bj0480383

  日期：1951.3.1
• Studies on Oxythiamine
  作者：Morris Soodak、Leopold R. Cerecedo

  DOI：10.1021/ja01239a510

  日期：1944.11