4-((S)-3-benzylpiperazin-1-yl)-2-(1H-pyrazol-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine | 1438883-27-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-((S)-3-benzylpiperazin-1-yl)-2-(1H-pyrazol-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine
• 英文别名: 4-[(3S)-3-benzylpiperazin-1-yl]-2-(1H-pyrazol-4-yl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine
• CAS: 1438883-27-2
• 化学式: C₂₄H₂₆N₆S
• 分子量: 430.577
• InChiKey: IKMZQOUMYVZNRA-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  98
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C<br/>[FR] INHIBITEURS DE TYPE THIÉNOPYRIMIDINE DE PROTÉINES KINASES C ATYPIQUES
  申请人：CANCER REC TECH LTD

  公开号：WO2013078126A1

  公开（公告）日：2013-05-30

  The present invention provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have a PKC inhibitory activity, and may be used to treat proliferative disorders.

  本发明提供了一种式（I）的化合物或其盐，其中R1、R2、R3、R4、R5、R6、A、G、M、Q和X如本文所定义。式（I）的化合物及其盐具有PKC抑制活性，并可用于治疗增生性疾病。
• Thienopyrimidine Inhibitors of Atypical Protein Kinase C
  申请人：Cancer Research Technology Limited

  公开号：US20140323435A1

  公开（公告）日：2014-10-30

  The present application provides a compound of formula (I) or a salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

  本申请提供了公式（I）的化合物或其盐，其中R1、R2、R3、R4、R5、R6、A、G、M、Q和X的定义如本文所述。公式（I）的化合物及其盐具有aPKC抑制活性，可用于治疗增殖性疾病。
• THIENOPYRIMIDINE AS INHIBITORS OF ATYPICAL PROTEIN KINASE C
  申请人：Cancer Research Technology Limited

  公开号：EP3048106A1

  公开（公告）日：2016-07-27

  The present invention provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. The compound of formula (I) and its salts has aPKC inhibitory activity, and may be used to treat proliferative disorders.

  本发明提供了一种式 (I) 的化合物 或其盐，其中 R1、R2、R3、R4、R5、R6、A、G、M、Q 和 X 如本文所定义。式（I）化合物及其盐具有 PKC 抑制活性，可用于治疗增殖性疾病。
• Thienopyrimidine inhibitors of atypical protein kinase C
  申请人：Cancer Research Technology Limited

  公开号：US10183950B2

  公开（公告）日：2019-01-22

  The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

  本申请提供了一种式 (I) 的化合物 或其盐，其中 R1、R2、R3、R4、R5、R6、A、G、M、Q 和 X 如本文所定义。式（I）化合物及其盐具有 PKC 抑制活性，可用于治疗增殖性疾病。
• THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C
  申请人：Cancer Research Technology Limited

  公开号：EP2782917B1

  公开（公告）日：2016-03-02