3-(n-Propylamino)-piperidin | 25560-15-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(n-Propylamino)-piperidin
• 英文别名: 3-Propylamino-piperidin；piperidin-3-yl-propyl-amine；N-propylpiperidin-3-amine
• CAS: 25560-15-0
• 化学式: C₈H₁₈N₂
• 分子量: 142.244
• InChiKey: CBIBYLPZGDCTJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Process for producing 1-alkoxycarbonyl nitrogenous saturated heterocyclic derivative
  申请人：——

  公开号：US20040242888A1

  公开（公告）日：2004-12-02

  A method for producing N-protected heterocyclic compounds such as 1-alkoxycarbonyl-3-aminopyrrolidines through position-selective reaction at the nitrogen atom that constitutes the hetero ring of a nitrogen-containing saturated heterocyclic compound having two nitrogen atoms such as 3-aminopyrrolidine. A dialkyl dicarbonate (ROCO-O-COOR) is reacted with a nitrogen-containing saturated heterocyclic compounds having two nitrogen atoms, at pH of from 9 to 14 to obtain a high-purity 1-alkoxycarbonyl nitrogen-containing saturated heterocyclic compound.

  一种生产N-保护杂环化合物（例如1-烷氧羰基-3-氨基吡咯烷）的方法，通过在含有两个氮原子的氮杂环化合物（例如3-氨基吡咯烷）的杂环中构成氮原子的位置选择性反应。将双烷基碳酸酯（ROCO-O-COOR）与含有两个氮原子的氮杂环化合物在pH为9至14的条件下反应，可获得高纯度的1-烷氧羰基氮杂环化合物。
• PROCESS FOR PRODUCING 1-ALKOXYCARBONYL NITROGENOUS SATURATED HETEROCYCLIC DERIVATIVE
  申请人：Toray Fine Chemicals Co., Ltd.

  公开号：EP1460061A1

  公开（公告）日：2004-09-22

  A method for producing N-protected heterocyclic compounds such as 1-alkoxycarbonyl-3-aminopyrrolidines through position-selective reaction at the nitrogen atom that constitutes the hetero ring of a nitrogen-containing saturated heterocyclic compound having two nitrogen atoms such as 3-aminopyrrolidine. A dialkyl dicarbonate (ROCO-O-COOR) is reacted with a nitrogen-containing saturated heterocyclic compounds having two nitrogen atoms, at pH of from 9 to 14 to obtain a high-purity 1-alkoxycarbonyl nitrogen-containing saturated heterocyclic compound.

  一种通过在具有两个氮原子的含氮饱和杂环化合物（如 3-氨基吡咯烷）中构成杂环的氮原子上进行位置选择性反应来生产 N 保护杂环化合物（如 1-烷氧羰基-3-氨基吡咯烷）的方法。将二烷基二碳酸酯（ROCO-O-COOR）与具有两个氮原子的含氮饱和杂环化合物在 pH 值为 9 至 14 的条件下进行反应，可得到高纯度的 1-烷氧基羰基含氮饱和杂环化合物。
• HETEROCYCLIC TYPE CINNAMIDE DERIVATIVE
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2019094A1

  公开（公告）日：2009-01-28

  Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product. (In the formula, Ar1 represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like; Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group or the like; X1 represents -CR3=CR4- (wherein R3 and R4 respectively represent a C1-6 alkyl group or the like); and R1 and R2 respectively represent a C1-6 alkyl group or the like.)

  本发明公开了下式 (I) 所代表的化合物或其药理上可接受的盐。还公开了该化合物或其盐作为药物产品的用途。 (式中，Ar1代表三唑基团或类似物，可被C1-6烷基或类似物取代；Ar2代表苯基或类似物，可被C1-6烷氧基或类似物取代；X1代表-CR3=CR4-(其中R3和R4分别代表C1-6烷基或类似物)；R1和R2分别代表C1-6烷基或类似物)。
• INHIBITORS OF HISTONE DEACETYLASE
  申请人：Methylgene, Inc.

  公开号：EP1663953A1

  公开（公告）日：2006-06-07
• US4472304A
  申请人：——

  公开号：US4472304A

  公开（公告）日：1984-09-18