Pt(II)(ethylenediamine)(OH)2 | 93967-25-0

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: Pt(II)(ethylenediamine)(OH)2
• 英文别名: [Pt(HO)2(ethane-1,2-diamine)]
• CAS: 93967-25-0
• 化学式: C₂H₁₀N₂O₂Pt
• 分子量: 289.194
• InChiKey: YVJAUHURISUSRT-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  Pt(II)(ethylenediamine)(OH)2 在 sodium chloride 作用下， 以 高氯酸 为溶剂， 生成 乙二胺氯化铂(II)
  参考文献：
  名称：

  The hydrolysis products of cis-diamminedichloroplatinum(II) 6. A kinetic comparison of the cis- and trans-isomers and other cis-di(amine)di(chloro)platinum(II) compounds

  摘要：

  Di(amine)di(chloro)platinum(II) complexes react in aqueous acid solution to form an equilibrium mixture L2PtCl2 k-1 reversible kj L2PtCl(OH2)+ + Cl-. Values of k1, K-1 and the equilibrium constant K(T) (-k1/k-1) have been measured for the systems L2 = cis(NH3)2, trans(NH3)2, cis(py)2, en, RR-chxn, tn and Me2tn, with varying temperature and ionic strength (cis(NH3)2 only). At 25-degrees-C and I = 0.1 M, data for cis-PtCl2(NH3)2 are k1 = 5.18 x 10(-5) s-1 (DELTA-H# = 86.7 kJ mol-1, DELTA-S# = -36 J K mol-1), k1 = 7.68 x 10(-3) M-1 s-1 (DELTA-H# - 72.7, DELTA-S# = - 41) and K1 = 6.74 x 10(-3). Corresponding data for trans-PtCl2(NH3)2 are k1 = 1.90 x 10(-5) s-1 (DELTA-H# = 92.2, DELTA-S# = - 26), k-1 - 3.05 x 10(-2) M-1 s-1 (DELTA-H# = 85.7, DELTA-S# = + 14) and K1 = 6.22 x 10(-4). These data provide a kinetic explanation for the inactivity of the trans-isomer as an anti-cancer drug.

  DOI：

  10.1016/s0020-1693(00)80242-x
• 作为产物：
  描述：

  乙二胺氯化铂(II) 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 Pt(II)(ethylenediamine)(OH)2
  参考文献：
  名称：

  The hydrolysis products of cis-diamminedichloroplatinum(II) 6. A kinetic comparison of the cis- and trans-isomers and other cis-di(amine)di(chloro)platinum(II) compounds

  摘要：

  Di(amine)di(chloro)platinum(II) complexes react in aqueous acid solution to form an equilibrium mixture L2PtCl2 k-1 reversible kj L2PtCl(OH2)+ + Cl-. Values of k1, K-1 and the equilibrium constant K(T) (-k1/k-1) have been measured for the systems L2 = cis(NH3)2, trans(NH3)2, cis(py)2, en, RR-chxn, tn and Me2tn, with varying temperature and ionic strength (cis(NH3)2 only). At 25-degrees-C and I = 0.1 M, data for cis-PtCl2(NH3)2 are k1 = 5.18 x 10(-5) s-1 (DELTA-H# = 86.7 kJ mol-1, DELTA-S# = -36 J K mol-1), k1 = 7.68 x 10(-3) M-1 s-1 (DELTA-H# - 72.7, DELTA-S# = - 41) and K1 = 6.74 x 10(-3). Corresponding data for trans-PtCl2(NH3)2 are k1 = 1.90 x 10(-5) s-1 (DELTA-H# = 92.2, DELTA-S# = - 26), k-1 - 3.05 x 10(-2) M-1 s-1 (DELTA-H# = 85.7, DELTA-S# = + 14) and K1 = 6.22 x 10(-4). These data provide a kinetic explanation for the inactivity of the trans-isomer as an anti-cancer drug.

  DOI：

  10.1016/s0020-1693(00)80242-x

文献信息

• A Novel Class of Bis- and Tris-Chelate Diam(m)inebis(dicarboxylato)platinum(IV) Complexes as Potential Anticancer Prodrugs
  作者：Hristo P. Varbanov、Simone Göschl、Petra Heffeter、Sarah Theiner、Alexander Roller、Frank Jensen、Michael A. Jakupec、Walter Berger、Mathea Sophia Galanski、Bernhard K. Keppler

  DOI：10.1021/jm500791c

  日期：2014.8.14

  A novel class of platinum(IV) complexes of the type [Pt(Am)(R(COO)2)2], where Am is a chelating diamine or two monodentate am(m)ine ligands and R(COO)2 is a chelating dicarboxylato moiety, was synthesized. For this purpose, the reaction between the corresponding tetrahydroxidoplatinum(IV) precursors and various dicarboxylic acids, such as oxalic, malonic, 3-methylmalonic, and cyclobutanedicarboxylic

  [Pt(Am)(R(COO) 2 ) 2 ]类型的新型铂 (IV) 配合物，其中 Am 是螯合二胺或两个单齿胺(m)ine 配体和 R(COO) 2是一种螯合的二羧基部分，是合成的。为此目的，利用了相应的四羟基铂（IV）前体与各种二羧酸（例如草酸、丙二酸、3-甲基丙二酸和环丁二羧酸）之间的反应。使用 1D 和 2D NMR 技术、ESI-MS、FTIR 光谱、元素分析、TGA 和 X 射线衍射对所有新化合物进行了详细表征。通过 MTT 比色法测定一组人肿瘤细胞系（CH1、SW480 和 A549）的体外细胞毒性。此外，为了更好地了解它们的药理行为，对新型复合物的亲脂性和氧化还原特性进行了评估。最有希望的候选药物，4b (Pt(DACH)(mal) 2)，对 L1210 白血病和 CT-26 结肠癌模型表现出低体内毒性但具有很强的抗癌活性。
• The hydrolysis products of cis-diamminedichloroplatinum(II) 8. Kinetics of the base hydrolysis of PtCl2(AA) (AA=en, chxn, Tn, Me2tn) and trans-PtCl2(NH3)2
  作者：Carol J. Abraham、Kathryn J. Gerard、Donald A. House

  DOI：10.1016/s0020-1693(00)85131-2

  日期：1993.7
• Murakami, Satomi; Muromatsu, Akihiko; Moriyasu, Masataka, Nippon Kagaku Kaishi/Journal of the Chemical Society of Japan
  作者：Murakami, Satomi、Muromatsu, Akihiko、Moriyasu, Masataka、Hashimoto, Yohei

  DOI：——

  日期：——
• Linkage isomerism of organoplatinum(II) compounds coordinated by two 1,3-dimethylbarbiturate anions
  作者：Kishie Noguchi、Takashi Tamura、Hidetaka Yuge、Takeshi Ken Miyamoto

  DOI：10.1107/s0108270199014109

  日期：2000.2.15

  In two linkage isomers, bis[1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrionato]-C-5,O-4-(ethylenediamine-N,N')platinum(II), [Pt(C6H7N2O3)(2)(C2H8N2)], (I), and bis[1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrionato-C5](ethylenediamine-N,N')platinum(II) dihydrate, [Pt(C6H7N2O3)(2)(C2H8N2)]. 2H(2)O, (II), crystallized from the same aqueous solution containing [Pt(en)(OH)(2)] and 1,3-dimethylbarbituric acid (Hdmbarb) in a 1:2 molar ratio, a pair of monodentate dmbarb(-) anions coordinate to the Pt atom at tetrahedral C atoms for (II), while one dmbarb- anion coordinates at the carbon and the other at a deprotonated enol oxygen for (I). The Pt-C distances in (1) and (II) are comparable: 2.112 (4) Angstrom for (I), and 2.114 (4) and 2.117 (4) Angstrom for (II).