2-Phenyl-1-<4>piperidyl-ethan-1-ol | 24152-51-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Phenyl-1-<4>piperidyl-ethan-1-ol
• 英文别名: 2-Phenyl-1-(4-piperidyl)-ethan-1-ol；2-phenyl-1-piperidin-4-yl-ethanol；2-Phenyl-1-piperidin-4-ylethanol
• CAS: 24152-51-0
• 化学式: C₁₃H₁₉NO
• 分子量: 205.3
• InChiKey: QLQFYCNTRVMVIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Piperidin ether derivatives as psychotropic drugs or plant fungicides
  申请人：THE DU PONT MERCK PHARMACEUTICAL COMPANY

  公开号：EP0449187A2

  公开（公告）日：1991-10-02

  There are provided piperidine ether derivatives (I) pharmaceutical and agricultural compositions containing them useful for treating physiological or drug induced psychosis or dyskinesia in a mammal or fungal disease in plants. Also provided are methods for preparing these compounds.

  本发明提供了哌啶醚衍生物(I)以及含有哌啶醚衍生物(I)的药物和农用组合物，用于治疗哺乳动物的生理性或药物诱发的精神错乱或运动障碍，或植物的真菌病。还提供了制备这些化合物的方法。
• 2-Oxadiazolyl- or 2-thiadiazolyl-phenylcarbamate and -phenylurea derivatives, their preparation and their use as intermediates
  申请人：GLAXO GROUP LIMITED

  公开号：EP0972773A1

  公开（公告）日：2000-01-19

  The present invention relates to substituted carbamates and ureas of formula (V) wherein R1 represents a hydrogen or a halogen atom, or a C1-6alkyl, C1-6alkoxy or hydroxy group; R2 represents an oxadiazole or thiadiazole ring substituted by a group selected from C1-6alkyl, C3-7cycloalkyl, -CH2C2-5alkenyl, -CH2C2-5alkynyl, phenyl or benzyl; X represents NH or an oxygen atom; and m represents zero, 1 or 2; which compounds are intermediates in the preparation of certain therapeutically active substituted phenylcarbamates and ureas.

  本发明涉及式（V）的取代氨基甲酸酯和脲，其中 R1 代表氢或卤原子，或 C1-6烷基、C1-6烷氧基或羟基；R2 代表被选自 C1-6烷基、C3-7环烷基、-CH2C2-5烯基、-CH2C2-5炔基、苯基或苄基的基团取代的噁二唑或噻二唑环； X代表NH或氧原子；m代表0、1或2；这些化合物是制备某些具有治疗活性的取代苯基氨基甲酸酯和脲的中间体。
• SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT ANTAGONISTS
  申请人：GLAXO GROUP LIMITED

  公开号：EP0640081A1

  公开（公告）日：1995-03-01
• DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT 4? ANTAGONISTIC ACTIVITY
  申请人：BOEHRINGER INGELHEIM ITALIA S.p.A.

  公开号：EP0815080A1

  公开（公告）日：1998-01-07
• DERIVES DE TRIAZOLES ET TETRAZOLES, ET LEUR UTILISATION EN THERAPEUTIQUE
  申请人：SANOFI-SYNTHELABO

  公开号：EP1150972A1

  公开（公告）日：2001-11-07