hexadecylphosphinic acid | 2629-28-9

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: hexadecylphosphinic acid
• CAS: 2629-28-9
• 化学式: C₁₆H₃₅O₂P
• 分子量: 290.426
• InChiKey: WEDMRADKYHIADJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  19
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  hexadecylphosphinic acid 在 偶氮二异丁腈 作用下， 反应 156.0h， 生成 methyl [(1-methylpiperidin-4-yl)methyl](hexadecyl)phosphinate
  参考文献：
  名称：

  Synthesis of a phosphinate analogue of the anti-tumour phosphate di-ester perifosine via sequential radical processes

  摘要：

  描述了一种高效的抗肿瘤磷酸二酯 perifosine 的膦酸酯类似物合成方法（6 步反应，总产率为 50%）。perifosine 类似物中的两个磷碳键是通过连续的双自由基亲水膦酰化过程制备的。这是第一个针对磷脂代谢酶水解耐受性设计的 perifosine 膦酸酯类似物的例子。

  DOI：

  10.1039/c2ob26395e
• 作为产物：
  描述：

  十六碳烯 在 sodium hypophosphite 、 偶氮二异丁腈 、 硫酸 作用下， 以 乙醇 为溶剂， 反应 26.0h， 以91%的产率得到hexadecylphosphinic acid
  参考文献：
  名称：

  Synthesis of phosphinate analogues of the phospholipid anti-tumour agent hexadecylphosphocholine (miltefosine)

  摘要：

  Efficient synthesis of phosphinate analogues (in six steps and 68-69% overall yields) of the anti-tumour agent miltefosine are reported, which involve a radical hydrophosphinylation addition reaction followed by conversion to the P(III) silyloxy intermediate and Michael-type addition as the key steps. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.03.107

文献信息

• Method for the production of alkylphosphonic acids, esters, and salts by oxidizing alkylphosphonous acids, and use thereof
  申请人：Hill Michael

  公开号：US09018413B2

  公开（公告）日：2015-04-28

  The invention relates to a method for producing monocarboxy-functionalized dialkylphosphinic acids, esters, and salts, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) in the presence of a catalyst A to obtain an alkylphosphonous acid, the salt or ester (II) thereof, and b) the obtained alkylphosphonous acid, the salt or ester (II) thereof is reacted with an oxidizing agent or with an oxidizing agent and water or with oxygen and water in the presence of a catalyst B to obtain the alkylphosphonic acid derivative (III), wherein R1, R2, R3, R4 are identical or different from each other and independently represent, inter alia, H, C1-C18-alkyl, C6-C18-aryl, C6-C18-aralkyl, C6-C18-alkylaryl, X and Y are identical or different from each other and independently represent H, C1-C18-alkyl, C6-C18-aryl, C6-C18-aralkyl, C6-C18-alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogenous base, and catalysts A and B are transition metals and/or transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand.

  该发明涉及一种生产单羧基功能化二烷基膦酸、酯和盐的方法，其特征在于a)在催化剂A的存在下，将膦酸源(I)与烯烃(IV)反应，得到一种烷基膦酸、其盐或酯(II)，b)将所得的烷基膦酸、其盐或酯(II)与氧化剂或与氧化剂和水或与氧气和水在催化剂B的存在下反应，得到烷基膦酸衍生物(III)，其中R1、R2、R3、R4相同或不同，独立表示H、C1-C18-烷基、C6-C18-芳基、C6-C18-芳基烷基、C6-C18-烷基芳基，X和Y相同或不同，独立表示H、C1-C18-烷基、C6-C18-芳基、C6-C18-芳基烷基、C6-C18-烷基芳基、Mg、Ca、Al、Sb、Sn、Ge、Ti、Fe、Zr、Zn、Ce、Bi、Sr、Mn、Cu、Ni、Li、Na、K和/或质子化的氮碱基，催化剂A和B是过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物与至少一种配体组成的催化体系。
• Chemoselective synthesis of long-chain alkyl-<i>H</i>-phosphinic acids <i>via</i> one-pot alkylation/oxidation of red phosphorus with alkyl-PEGs as recyclable micellar catalysts
  作者：Vladimir A. Kuimov、Svetlana F. Malysheva、Natalia A. Belogorlova、Nina K. Gusarova、Boris A. Trofimov

  DOI：10.1039/d1ob01470f

  日期：——

  Long-chain n-alkyl-H-phosphinic acids (Alk = C4–C18) are chemoselectively synthesized in yields up to 90% via the direct one-pot alkylation/oxidation of red phosphorus (Pn) in the multi-phase alkyl bromide/KOH/H2O/toluene system with alkyl-PEG recyclable micellar catalysts, which demonstrate good recyclability.

  长链ñ -烷基- ħ -次膦酸（ALK = C 4 -C 18）的产率高达90％的化学选择性合成通过红磷（P的直接单罐烷基化/氧化Ñ在多相）烷基溴/KOH/H 2 O/甲苯体系与烷基-PEG 可回收胶束催化剂，表现出良好的可回收性。
• PHOTOSENSITIVE COMPOSITIONS, PREPARATION METHODS THEREOF, AND QUANTUM DOT POLYMER COMPOSITE PREPARED
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP3136174A1

  公开（公告）日：2017-03-01

  A photosensitive composition including a quantum dot dispersion, a reactive compound having at least two thiol groups, a photopolymerizable monomer having a carbon-carbon double bond, and a photoinitiator, wherein the quantum dot dispersion includes a carboxylic acid group -containing polymer and a quantum dot dispersed in the carboxylic acid group containing polymer, and wherein the carboxylic acid group-containing polymer includes a copolymer of a monomer combination including a first monomer having a carboxylic acid group and a carbon-carbon double bond and a second monomer having a carbon-carbon double bond and a hydrophobic moiety and not having a carboxylic acid group.

  一种光敏组合物，包括量子点分散体、具有至少两个硫醇基团的活性化合物、具有碳碳双键的可光聚合单体和光引发剂，其中量子点分散体包括含羧酸基团的聚合物和分散在含羧酸基团聚合物中的量子点、其中含羧酸基团聚合物包括单体组合的共聚物，该单体组合包括具有羧酸基团和碳碳双键的第一单体以及具有碳碳双键和疏水分子且不具有羧酸基团的第二单体。
• QUANTUM DOT HAVING POLYMERIC OUTER LAYER, PHOTOSENSITIVE COMPOSITIONS INCLUDING THE SAME, AND QUANTUM DOT POLYMER COMPOSITE PATTERN PRODUCED THEREFROM
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP3163372A2

  公开（公告）日：2017-05-03

  A photosensitive composition including a quantum dot complex having a polymeric outer layer, a carboxylic acid group-containing binder, a photopolymerizable monomer having a carbon-carbon double bond, a photoinitiator, and a solvent, wherein the polymeric outer layer includes a copolymer including a first repeating unit having a moiety capable of interacting with a surface of the quantum dot, an organic ligand compound bonded to the surface of the quantum dot, or a combination thereof, and a second repeating unit having a reactive moiety.

  一种光敏组合物，包括具有聚合物外层的量子点复合物、含羧酸基团的粘合剂、具有碳碳双键的可光聚合单体、光引发剂和溶剂，其中聚合物外层包括共聚物，共聚物包括具有能与量子点表面相互作用的分子的第一重复单元、与量子点表面结合的有机配体化合物或它们的组合，以及具有活性分子的第二重复单元。
• QUANTUM DOT-POLYMER MICRONIZED COMPOSITE, PRODUCTION METHOD THEREOF, AND ARTICLE AND ELECTRONIC DEVICE INCLUDING THE SAME
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP3187564A1

  公开（公告）日：2017-07-05

  A quantum dot-polymer micronized composite includes a first polymer matrix; a plurality of quantum dots dispersed in the first polymer matrix; and at least one of an additive selected from a clay particle embedded in the first polymer matrix and a metal halide dispersed in the first polymer matrix, wherein the quantum dot-polymer micronized composite has an average particle size of less than or equal to about 100 micrometers, a production method thereof, and an article and an electronic device including the micronized composite are provided.

  提供了一种量子点-聚合物微粉复合材料，包括第一聚合物基体；分散在第一聚合物基体中的多个量子点；以及选自嵌入第一聚合物基体中的粘土颗粒和分散在第一聚合物基体中的金属卤化物的至少一种添加剂，其中量子点-聚合物微粉复合材料的平均粒径小于或等于约100微米，还提供了其生产方法以及包括该微粉复合材料的物品和电子设备。