(S)-2-{2-[2-(11-Tritylsulfanyl-undecyloxy)-ethoxy]-acetylamino}-succinamic acid | 871725-06-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (S)-2-{2-[2-(11-Tritylsulfanyl-undecyloxy)-ethoxy]-acetylamino}-succinamic acid
• CAS: 871725-06-3
• 化学式: C₃₈H₅₀N₂O₆S
• 分子量: 662.891
• InChiKey: GOVWULLGKGNNTH-UMSFTDKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  47.0
• 可旋转键数：
  25.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  127.95
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (S)-2-{2-[2-(11-Tritylsulfanyl-undecyloxy)-ethoxy]-acetylamino}-succinamic acid 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 (S)-2-{2-[2-(11-Mercapto-undecyloxy)-ethoxy]-acetylamino}-succinamic acid
  参考文献：
  名称：

  Contrasting Effects of Exterior and Interior Hydrophobic Moieties in the Complexation of Amino Acid Functionalized Gold Clusters with α-Chymotrypsin

  摘要：

  A series Of L-amino acid functionalized gold nanoparticles with oligo(ethylene glycol) (OEG) tethers of varying length are prepared. These studies show that the hydrophobic side chains of amino acids facilitate the structural retention of alpha-chymotrypsin (ChT) but the interior alkyl chains promote its denaturation. An 80-fold range of denaturation rate constants were obtained for ChT in the presence of various nanoparticles. Thus, the tunable denaturation of protein could be achieved by rational combination of amino acid side chains and OEG tethers.

  DOI：

  10.1021/ol052367k
• 作为产物：
  描述：

  在 碳酸氢钠 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 48.0h， 生成 (S)-2-{2-[2-(11-Tritylsulfanyl-undecyloxy)-ethoxy]-acetylamino}-succinamic acid
  参考文献：
  名称：

  Contrasting Effects of Exterior and Interior Hydrophobic Moieties in the Complexation of Amino Acid Functionalized Gold Clusters with α-Chymotrypsin

  摘要：

  A series Of L-amino acid functionalized gold nanoparticles with oligo(ethylene glycol) (OEG) tethers of varying length are prepared. These studies show that the hydrophobic side chains of amino acids facilitate the structural retention of alpha-chymotrypsin (ChT) but the interior alkyl chains promote its denaturation. An 80-fold range of denaturation rate constants were obtained for ChT in the presence of various nanoparticles. Thus, the tunable denaturation of protein could be achieved by rational combination of amino acid side chains and OEG tethers.

  DOI：

  10.1021/ol052367k