(R)-N-[(R)-1-(diphenyl(3-(tetrahydro-2H-pyran-2-yloxy)propyl)silyl)-4-hydroxybutyl]-2-methylpropane-2-sulfinamide | 1239471-61-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (R)-N-[(R)-1-(diphenyl(3-(tetrahydro-2H-pyran-2-yloxy)propyl)silyl)-4-hydroxybutyl]-2-methylpropane-2-sulfinamide
• CAS: 1239471-61-4
• 化学式: C₂₈H₄₃NO₄SSi
• 分子量: 517.805
• InChiKey: YCWILTDYBQDENW-CTFHROIPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.92
• 重原子数：
  35.0
• 可旋转键数：
  13.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  67.79
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (R)-N-[(R)-1-(diphenyl(3-(tetrahydro-2H-pyran-2-yloxy)propyl)silyl)-4-hydroxybutyl]-2-methylpropane-2-sulfinamide 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 20.0h， 生成
  参考文献：
  名称：

  Stereocontrolled Synthesis of 2-Substituted-1,3-Azasilaheterocycles

  摘要：

  Chiral alpha-silylsulfinamides, prepared by the treatment of an alkyldiphenylsilane with lithium followed by its addition to a sulfinimine, can be applied to the synthesis of 1,3-azasilaheterocycles as derivatives of cyclic alkaloids. This synthetic route, which involves intramolecular substitution of an amino alcohol or cyclization of an amino acid promoted by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), represents a convenient means for accessing these silicon-containing heterocycles.

  DOI：

  10.1021/ol101379t
• 作为产物：
  描述：

  (R)-N-[(1R)-1-(diphenyl(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silyl)-4-((4-methoxybenzyl)oxy)butyl]-2-methylpropane-2-sulfinamide 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 3.0h， 以94%的产率得到(R)-N-[(R)-1-(diphenyl(3-(tetrahydro-2H-pyran-2-yloxy)propyl)silyl)-4-hydroxybutyl]-2-methylpropane-2-sulfinamide
  参考文献：
  名称：

  Stereocontrolled Synthesis of 2-Substituted-1,3-Azasilaheterocycles

  摘要：

  Chiral alpha-silylsulfinamides, prepared by the treatment of an alkyldiphenylsilane with lithium followed by its addition to a sulfinimine, can be applied to the synthesis of 1,3-azasilaheterocycles as derivatives of cyclic alkaloids. This synthetic route, which involves intramolecular substitution of an amino alcohol or cyclization of an amino acid promoted by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), represents a convenient means for accessing these silicon-containing heterocycles.

  DOI：

  10.1021/ol101379t