(E)-N,N'-Bis-[4-(trityl-amino)-butyl]-N,N'-bis-[3-(trityl-amino)-propyl]-but-2-ene-1,4-diamine | 244033-26-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (E)-N,N'-Bis-[4-(trityl-amino)-butyl]-N,N'-bis-[3-(trityl-amino)-propyl]-but-2-ene-1,4-diamine
• CAS: 244033-26-9
• 化学式: C₉₄H₉₈N₆
• 分子量: 1311.85
• InChiKey: VODYSWDLIZWMDO-WQVHNPAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  18.81
• 重原子数：
  100.0
• 可旋转键数：
  38.0
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  54.6
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (E)-N,N'-Bis-[4-(trityl-amino)-butyl]-N,N'-bis-[3-(trityl-amino)-propyl]-but-2-ene-1,4-diamine 在 盐酸 作用下， 生成
  参考文献：
  名称：

  Synthesis of spermidine and norspermidine dimers as high affinity polyamine transport inhibitors

  摘要：

  A series of novel spermidine and sym-norspermidine dimers was synthesized by crosslinking the polyamine backbones via alkylation of their secondary amino groups to butyl, trans-2-butenyl, 2-butynyl or p-xylyl bridges. The resulting hexamines behaved as high-affinity antagonists of polyamine uptake, with a relative potency that was dependent on the geometry of the linker structure. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00262-0
• 作为产物：
  描述：

  亚精胺 在 potassium carbonate 、 三乙胺 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 生成 (E)-N,N'-Bis-[4-(trityl-amino)-butyl]-N,N'-bis-[3-(trityl-amino)-propyl]-but-2-ene-1,4-diamine
  参考文献：
  名称：

  Synthesis of spermidine and norspermidine dimers as high affinity polyamine transport inhibitors

  摘要：

  A series of novel spermidine and sym-norspermidine dimers was synthesized by crosslinking the polyamine backbones via alkylation of their secondary amino groups to butyl, trans-2-butenyl, 2-butynyl or p-xylyl bridges. The resulting hexamines behaved as high-affinity antagonists of polyamine uptake, with a relative potency that was dependent on the geometry of the linker structure. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00262-0