5'-O-dimethoxytrityl-2-N-[tris(N,N',N"-trifluoroacetyl)-4,9,13-triazatridecane-1-yl]-2'-deoxyguanosine | 244639-84-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5'-O-dimethoxytrityl-2-N-[tris(N,N',N"-trifluoroacetyl)-4,9,13-triazatridecane-1-yl]-2'-deoxyguanosine
• 英文别名: N-[3-[4-[3-[[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]amino]propyl-(2,2,2-trifluoroacetyl)amino]butyl-(2,2,2-trifluoroacetyl)amino]propyl]-2,2,2-trifluoroacetamide
• CAS: 244639-84-7
• 化学式: C₄₇H₅₁F₉N₈O₉
• 分子量: 1042.96
• InChiKey: RQDSFIIWNXIPHA-LIVOIKKVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  73
• 可旋转键数：
  23
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  198
• 氢给体数：
  4
• 氢受体数：
  20

反应信息

• 作为产物：
  描述：

  2-fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine 在 吡啶 作用下， 反应 48.0h， 生成 5'-O-dimethoxytrityl-2-N-[tris(N,N',N"-trifluoroacetyl)-4,9,13-triazatridecane-1-yl]-2'-deoxyguanosine
  参考文献：
  名称：

  Synthesis of Polyaminooligonucleotides and Their Combinatorial Libraries

  摘要：

  A synthesis of phosphoramidites of 2'-deqxyadenosine and 2'-deoxyguanosine carrying a protected spermine moiety at N-6 and N-2 positions respectively is described. An approach to analyse properties of polyaminooligonucleotides using their synthetic combinatorial libraries is described and discussed. A synthesis of a polyaminooligonucleotide combinatorial library was carried out and the analysis of the library clearly showed that the presence of spermine moieties in oligodeoxyribonucleotides increases stability of their complexes.

  DOI：

  10.1080/07328319908044749