| 1441387-88-7

• CAS: 1441387-88-7
• 化学式: C₄₈H₅₆N₆O₁₀Sn₂
• 分子量: 1114.43
• InChiKey: DHKIZCRVQJWMKD-JDDOGQBLSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  吡啶-2-甲醛 、 间苯二甲酸 、 二正丁基氧化锡 、 2-氨基-4-硝基苯酚 以 甲醇 为溶剂， 反应 2.0h， 以81%的产率得到
  参考文献：
  名称：

  Dinuclear heptacoordinate dibutyltin (IV) complexes derived from Schiff bases and dicarboxylates: Synthesis, cytotoxicity, and antioxidant activity

  摘要：

  The synthesis of dinuclear dibutyltin (IV) complexes 1a-4d, prepared in one pot by the reaction of 2-amino-4-R-phenol (R = H, Me, Cl, NO2), 2-pyridinecarboxaldehyde, dicarboxylic (2,5-pyridinedicarboxylic, terephthalic, isophthalic, and oxalic) acids and dibutyltin oxides, is described. The complexes were characterized using IR, MS and H-1, C-13 and Sn-119 NMR techniques. The molecular structures of complexes 1a, 1c and 4c were established using X-Ray diffraction, and these complexes exhibited a distorted pentagonal-bipyramidal (BPT) geometry in which the equatorial plane consisted of three oxygen atoms and two nitrogen atoms, and the butyl groups occupied the axial positions. The cytotoxicity of the terephthalic acid derivatives 1a-d in HCT-15 colon cancer, MCF7 breast cancer and PC3 prostate cancer cell lines was investigated in vitro. The antioxidant activity of these complexes was also measured using the DPPH (1,1-diphenyl-2-picrylhydrazyl) assay. (C) 2013 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2013.03.038