N,N-diisopropylpiperidine-1-carboxamide | 1621476-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N,N-diisopropylpiperidine-1-carboxamide
• 英文别名: N,N-di(propan-2-yl)piperidine-1-carboxamide
• CAS: 1621476-75-2
• 化学式: C₁₂H₂₄N₂O
• 分子量: 212.335
• InChiKey: JGGLQIWURPCTRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  、 N,N-diisopropylpiperidine-1-carboxamide 以 二氯甲烷 为溶剂， 反应 2.0h， 以88%的产率得到
  参考文献：
  名称：

  Synthetic and structural studies of piperidine carboxamide uranyl ion complexes

  摘要：

  New piperidine based ligands of the type [C5H10NCONR2] (where R = CH3 (L1), C2H5 (L2) and (C3H7)-C-i (L3)) have been prepared and characterized. The complex chemistry of these ligands with uranyl chloride, bromide, nitrate and beta-diketonates has been studied using IR and NMR spectroscopic methods. Crystal structures for the complexes [UO2Cl2(L3)(2)] (1), [UO2Br2(L3)(2)] (2) [UO2(NO3)(2)(L3)(2)] (5) and [UO2(C4H3SCOCHCOCF3)(2)(L3)] (8) have been determined by the X-ray diffraction method. The structures of 1 and 2 show that the uranyl ion is surrounded by two of the ligands and two halogen atoms in an octahedral geometry. The structure of 5 shows that the uranyl group is surrounded by two nitrate groups and two ligands in a hexagonal bipyramidal geometry. The structure of 8 shows that the uranyl group is surrounded by two beta-diketonates and one ligand in a pentagonal bipyramidal geometry. The structures show that the carboxamide ligands are strongly bonded to the uranyl group, showing a near linear geometry for the U-O-C bond (angle 150-159 degrees). The prepared chloro and bromo compounds are air and moisture stable and show good solubility in normal organic solvents. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2014.05.037
• 作为产物：
  描述：

  哌啶 、 二异丙基甲胺酰氯 在 三乙胺 作用下， 以 苯 为溶剂， 反应 2.0h， 以94%的产率得到N,N-diisopropylpiperidine-1-carboxamide
  参考文献：
  名称：

  Synthetic and structural studies of piperidine carboxamide uranyl ion complexes

  摘要：

  New piperidine based ligands of the type [C5H10NCONR2] (where R = CH3 (L1), C2H5 (L2) and (C3H7)-C-i (L3)) have been prepared and characterized. The complex chemistry of these ligands with uranyl chloride, bromide, nitrate and beta-diketonates has been studied using IR and NMR spectroscopic methods. Crystal structures for the complexes [UO2Cl2(L3)(2)] (1), [UO2Br2(L3)(2)] (2) [UO2(NO3)(2)(L3)(2)] (5) and [UO2(C4H3SCOCHCOCF3)(2)(L3)] (8) have been determined by the X-ray diffraction method. The structures of 1 and 2 show that the uranyl ion is surrounded by two of the ligands and two halogen atoms in an octahedral geometry. The structure of 5 shows that the uranyl group is surrounded by two nitrate groups and two ligands in a hexagonal bipyramidal geometry. The structure of 8 shows that the uranyl group is surrounded by two beta-diketonates and one ligand in a pentagonal bipyramidal geometry. The structures show that the carboxamide ligands are strongly bonded to the uranyl group, showing a near linear geometry for the U-O-C bond (angle 150-159 degrees). The prepared chloro and bromo compounds are air and moisture stable and show good solubility in normal organic solvents. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2014.05.037

文献信息

• Iridium-Catalyzed Enantioselective α-C(sp³)–H Borylation of Azacycles
  作者：Lili Chen、Yuhuan Yang、Luhua Liu、Qian Gao、Senmiao Xu

  DOI：10.1021/jacs.0c06756

  日期：2020.7.15

  enantioselective α-C(sp3)-H borylation of a wide range of azacycles. The combination of an iridium precursor and a chiral bidentate boryl ligand has shown effectively differentiating enantiotropic methylene C-H bonds from a single carbon center, affording a variety of synthetically useful cyclic amines from readily available starting materials with good to excellent enantioselectivities.

  我们在此报告了铱催化的多种氮杂环的对映选择性 α-C(sp3)-H 硼酸化。铱前体和手性双齿硼基配体的组合已显示有效区分对映亚甲基 CH 键与单个碳中心，从易于获得的起始材料中提供各种合成有用的环胺，具有良好到出色的对映选择性。
• MUSCARINIC M1 RECEPTOR AGONISTS
  申请人：Heptares Therapeutics Limited

  公开号：US20170157139A1

  公开（公告）日：2017-06-08

  This invention relates to compounds that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula I, where n is 1 or 2; p is 0, 1 or 2; q is 0, 1 or 2; and R 1 -R 6 are as defined herein.
• US9907805B2
  申请人：——

  公开号：US9907805B2

  公开（公告）日：2018-03-06