(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-4-phenylpiperidin-1-yl)prop-2-en-1-one | 1192602-60-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-4-phenylpiperidin-1-yl)prop-2-en-1-one
• CAS: 1192602-60-0
• 化学式: C₂₀H₂₁NO₄
• 分子量: 339.391
• InChiKey: GELISJMJNTULQZ-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  81
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-苯基-4-羟基哌啶 、 3-bromo-7-(triisopropylsilyloxy)chroman-4-one 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以34%的产率得到(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-4-phenylpiperidin-1-yl)prop-2-en-1-one
  参考文献：
  名称：

  Synthesis and dopaminergic activity of some E-3-(piperidin-1-yl)-1-(4-substituted phenyl)prop-2-en-1-one derivatives

  摘要：

  A convenient route for the synthesis of some 2-propen-1-one derivatives with E isomeric configuration is described. The activity of the synthesized compounds was evaluated through behavioral studies of apomorphine-induced licking in animal models. It was demonstrated that most of the synthesized compounds showed moderate activity in inhibition of lickings, among which 6a, was the most active compound at 30 mg/kg. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.08.030

文献信息

• Synthesis and dopaminergic activity of some E-3-(piperidin-1-yl)-1-(4-substituted phenyl)prop-2-en-1-one derivatives
  作者：Amirhossein Sakhteman、Alireza Foroumadi、Mohammad Sharifzadeh、Masoud Amanlou、Farhoud Rayatnia、Abbas Shafiee

  DOI：10.1016/j.bmc.2009.08.030

  日期：2009.10

  A convenient route for the synthesis of some 2-propen-1-one derivatives with E isomeric configuration is described. The activity of the synthesized compounds was evaluated through behavioral studies of apomorphine-induced licking in animal models. It was demonstrated that most of the synthesized compounds showed moderate activity in inhibition of lickings, among which 6a, was the most active compound at 30 mg/kg. (C) 2009 Elsevier Ltd. All rights reserved.