Nojirimycin, 5-Amino-5-desoxy-α-D-glucopyranose, α-D-Glucopiperidinose | 121251-50-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Nojirimycin, 5-Amino-5-desoxy-α-D-glucopyranose, α-D-Glucopiperidinose
• 英文别名: 1-β-Nojirimycin, 5-Amino-5-desoxy-β-D-glucopyranose；6-hydroxymethyl-piperidine-2,3,4,5-tetraol；2,3,4,5-Piperidinetetrol, 6-(hydroxymethyl)-；6-(hydroxymethyl)piperidine-2,3,4,5-tetrol
• CAS: 121251-50-1
• 化学式: C₆H₁₃NO₅
• 分子量: 179.173
• InChiKey: BGMYHTUCJVZIRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  113
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• PARASITIC PLANT CONTROL AGENT AND PARASITIC PLANT CONTROL METHOD
  申请人：Osaka University

  公开号：EP2351484A1

  公开（公告）日：2011-08-03

  In order to provide a parasitic plant control agent and a parasitic plant control method each of which is capable of controlling a parasitic plant effectively, a parasitic plant is controlled by inhibiting gentianose metabolism in the parasitic plant so as to inhibit germination of the parasitic plant.

  为了提供一种能够有效控制寄生植物的寄生植物控制剂和寄生植物控制方法，我们通过抑制寄生植物的龙胆糖代谢来控制寄生植物，从而抑制寄生植物的发芽。
• Microbiological process
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：US10077458B2

  公开（公告）日：2018-09-18

  A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolating an imino sugar produced by said microorganism, and the microorganisms used in this process. The invention also comprises migalastat produced according to the above method and pharmaceutical compositions and uses thereof.

  一种微生物合成米加司他的工艺，具体地说是一种生产米加司他的工艺，包括在能产生至少一种亚氨基糖的条件下培养微生物，并检测和/或分离由所述微生物产生的亚氨基糖，以及在此工艺中使用的微生物。本发明还包括根据上述方法生产的米加司他及其药物组合物和用途。
• MICROBIOLOGICAL PROCESS
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：EP3108002A1

  公开（公告）日：2016-12-28
• Microbiological Process
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：US20180208955A1

  公开（公告）日：2018-07-26

  A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolating an imino sugar produced by said microorganism, and the microorganisms used in this process. The invention also comprises migalastat produced according to the above method and pharmaceutical compositions and uses thereof.
• US4339585A
  申请人：——

  公开号：US4339585A

  公开（公告）日：1982-07-13