9-(2H-1,3-Benzodioxol-5-yl)-6,7-dimethoxy-1-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl hexopyranoside

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 木脂素苷
• 英文名称: 9-(2H-1,3-Benzodioxol-5-yl)-6,7-dimethoxy-1-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl hexopyranoside
• 英文别名: 9-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3H-benzo[f][2]benzofuran-1-one
• 化学式: C₂₇H₂₆O₁₂
• 分子量: 542.5
• InChiKey: BJGIWVGXMRUMNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  163
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• [EN] ANTITUMOR ARYLNAPHTHALENE LIGAND GLYCOSIDES<br/>[FR] GLYCOSIDES DE LIGANDS ARYLNAPHTALÈNES ANTITUMORAUX
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2017147624A1

  公开（公告）日：2017-08-31

  Described are arylnaphthalene lactone derivatives. Also disclosed herein are methods of use of the arylnaphthalene lactone derivatives as anticancer agents.

  描述了芳基萘内酯衍生物。本文还披露了将芳基萘内酯衍生物用作抗癌剂的方法。
• Antitumor arylnaphthalene ligand glycosides
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：US10682367B2

  公开（公告）日：2020-06-16

  Described are arylnaphthalene lactone derivatives. Also disclosed herein are methods of use of the arylnaphthalene lactone derivatives as anticancer agents.

  本文描述的是芳基萘内酯衍生物。 本文还公开了使用芳基萘内酯衍生物作为抗癌剂的方法。
• ARYLNAPHTHALENE LACTONE DERIVATIVES AND METHODS OF MAKING AND USING THEREOF
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：US20170119806A1

  公开（公告）日：2017-05-04

  A series of natural products including phyllanthusum, an arylnaphthalene lignan derivative, with anticancer and antitumor and immunostimulating activity are disclosed. The invention further encompasses methods of adding water solubilizing groups to the arylrings that include phosphonyl groups.
• ANTITUMOR ARYLNAPHTHALENE LIGAND GLYCOSIDES
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：US20190054105A1

  公开（公告）日：2019-02-21

  Described are arylnaphthalene lactone derivatives. Also disclosed herein are methods of use of the arylnaphthalene lactone derivatives as anticancer agents.