Camelinin | 75272-83-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 亚砜
• 英文名称: Camelinin
• 英文别名: (R)-10-methanesulfinyl-decyl isothiocyanate；(R)-(10-Isothiocyanato-decyl)-methyl-sulfoxid；(R)-10-Methansulfinyl-decylisothiocyanat；10-methylsulfinyldecyl isothiocyanate；1-isothiocyanato-10-methylsulfinyldecane
• CAS: 75272-83-2
• 化学式: C₁₂H₂₃NOS₂
• 分子量: 261.453
• InChiKey: BULCNSNGNSSTBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  80.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Camelinin 在 乙醇 、 氨 作用下， 生成 (R)-1-(10-Methylsulfinyldecyl)-thioharnstoff
  参考文献：
  名称：

  Kjaer et al., Acta Chemica Scandinavica (1947), 1956, vol. 10, p. 1614,1618

  摘要：

  DOI：

文献信息

• Treatment of helicobacter with isothiocyanates
  申请人：——

  公开号：US20020151505A1

  公开（公告）日：2002-10-17

  The present invention relates to methods of preventing or inhibiting the growth of Helicobacter through the use of a composition that comprises a glucosinolate, an isothiocyanate or a derivative or metabolite thereof. The present invention also relates to methods of preventing or treating persistent chronic gastritis, ulcers and/or stomach cancer in subjects at risk for, or in need of treatment thereof.

  本发明涉及通过使用包含葡萄糖苷酸盐、异硫氰酸盐或其衍生物或代谢物的组合物来预防或抑制螺旋杆菌生长的方法。本发明还涉及预防或治疗有患病风险或需要治疗的受试者的顽固性慢性胃炎、溃疡和/或胃癌的方法。
• Treatment of helicobacter with isothocyanates
  申请人：——

  公开号：US20040180843A1

  公开（公告）日：2004-09-16

  The present invention relates to methods of preventing or inhibiting the growth of Helicobacter through the use of a composition that comprises a glucosinolate, an isothiocyanate or a derivative or metabolite thereof. The present invention also relates to methods of preventing or treating persistent chronic gastritis, ulcers and/or stomach cancer in subjects at risk for, or in need of treatment thereof.

  本发明涉及通过使用包含葡萄糖苷酸盐、异硫氰酸盐或其衍生物或代谢物的组合物来预防或抑制螺旋杆菌生长的方法。本发明还涉及预防或治疗有患病风险或需要治疗的受试者的顽固性慢性胃炎、溃疡和/或胃癌的方法。
• Method of extraction of isothiocyanates into oil from glucosinolate-containing plants and method of producing products with oil containing isothiocyanates extracted from glucosinolate-containing plants
  申请人：Fahey W. Jed

  公开号：US20060127996A1

  公开（公告）日：2006-06-15

  A method of extraction of isothiocyanates into the oil from glucosinolate-containing plants. A method of preparing products including pharmaceutical compositions, food or drink products, supplements or additives, skin or hair products, and agricultural products which contain isothiocyanate oil extracted from glucosinolate-containing plants.

  一种从含葡萄糖苷酸的植物中提取异硫氰酸酯油的方法。一种制备含有从含葡萄糖苷酸植物中提取的异硫氰酸盐油的产品的方法，这些产品包括药物组合物、食品或饮料产品、补充剂或添加剂、皮肤或头发产品以及农产品。
• TREATMENT OF HELICOBACTER WITH ISOTHIOCYANATES
  申请人：Fahey, Jed W.

  公开号：EP1313377A2

  公开（公告）日：2003-05-28
• Methods and composition for the treatment of cystic fibrosis and related illnesses
  申请人：Childers Melanie

  公开号：US20060258599A1

  公开（公告）日：2006-11-16

  The present invention relates to methods and compositions to treat subjects having cystic fibrosis. These compositions comprise the class of isothiocyanates. Isothiocyanates, absorbed by a cell are conjugated with glutathione GSH by glutathione-s-tranferase (GST). The conjugates are substrates of the multi-drug resistance associated (MRP)/multi-drug resistance (MDR) proteins. These proteins are functionally redundant to the cystic fibrosis transmembrane conductance regulator (CFTR), allowing for the substrate conjugates to be exported from the cell. The export of GSH conjugates restores intracellular and extracellular levels of GSH to normal levels. Normalizing both extracellular and intracellular GSH via the increased conjugation of isothiocyanates with GSH, and subsequent export, can significantly rectify numerous enzymatic processes and correct the pathologies that are typical of patients suffering from cystic fibrosis.