2-Hydroxy-4-(3-hydroxy-4-methoxyphenyl)quinolizidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Hydroxy-4-(3-hydroxy-4-methoxyphenyl)quinolizidine
• 英文别名: 4-(3-hydroxy-4-methoxyphenyl)-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin-2-ol
• 化学式: C₁₆H₂₃NO₃
• 分子量: 277.36
• InChiKey: CRYPKWICPCFQOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  52.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PHARMACEUTICAL PREPARATIONS OF BIOACTIVE SUBSTANCES EXTRACTED FROM NATURAL SOURCES
  申请人：Armadillo Pharmaceuticals, Inc.

  公开号：EP1183039A1

  公开（公告）日：2002-03-06
• [EN] PHARMACEUTICAL PREPARATIONS OF BIOACTIVE SUBSTANCES EXTRACTED FROM NATURAL SOURCES<br/>[FR] PREPARATIONS PHARMACEUTIQUES DE SUBSTANCES BIOACTIVES EXTRAITES DE SOURCES NATURELLES
  申请人：ARMADILLO PHARMACEUTICALS INC

  公开号：WO2000072861A1

  公开（公告）日：2000-12-07

  This invention relates to methods of extracting and purifying bioactive substances from various plants and herbs. More specifically the invention relates to methods of extracting and separating bioactive substances from various plants and herbs, such as Kava root, Byrsonima species, Aesculus californica, Crataegus mexicana, Simmondsia chinensis, Pfaffia species, Alternanthera repens, Bursera species, Turnera species, Perezia species, Heimia salicifolia, Psidium species, Enterlobium species, Ptychopetalum olacoides, Liriosma ovata, and Chaunochiton kappleri, using supercritical fluid extraction and/or fluorocarbon solvent extract. The present invention further relates to separation of bioactive substances contained in extracts using packed column supercritical fluid chromatography or HPLC where dense gas with or without modifiers is the mobile phase. The present invention also relates to pharmaceutical preparations and dietary supplements which may be prepared with the extracted bioactive substances and use of such pharmaceutical preparations and dietary supplements to treat various human aliments.