5,6,7,8-Tetrahydropyrrolizin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯嗪
• 英文名称: 5,6,7,8-Tetrahydropyrrolizin-3-one
• 化学式: C₇H₉NO
• 分子量: 123.15
• InChiKey: FVZBHZCORGROSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• UCS1025 DERIVATIVES
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1227097A1

  公开（公告）日：2002-07-31

  UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I): wherein R1 represents hydrogen, lower alkyl, etc.; R2 represents hydrogen, or is combined with R3 to represent a bond, etc., or is combined with R4 to represent -O(C=O)-, etc.; R3 represents hydrogen, etc., or is combined with R2 to represent a bond, etc.; R4 represents hydrogen, etc., or is combined with R2 to represent -(C=O)O-, etc.; R5 represents hydrogen or is combined with R6 to represent a bond; R6 represents hydrogen, etc., or is combined with R5 to represent a bond; R7 represents hydrogen or is combined with R8 to represent =O; R8 represents hydroxy or is combined with R7 to represent =O; ---- represents a single bond or a double bond, and a represents a single bond (two carbon atoms to which a is bound are combined to form a single bond) or an oxygen atom, or pharmaceutically acceptable salts thereof.

  具有抗肿瘤活性或抗菌活性的 UCS 1025 衍生物，由式(I)表示： 其中 R1 代表氢、低级烷基等； R2 代表氢，或与 R3 结合代表键等，或与 R4 结合代表-O(C=O)-等； R3 代表氢等，或与 R2 结合代表键等； R4 代表氢等，或与 R2 结合代表-(C=O)O-等； R5 代表氢，或与 R6 结合代表键等； R6 代表氢等、或与 R5 结合代表键；R7 代表氢或与 R8 结合代表 =O；R8 代表羟基或与 R7 结合代表 =O；---- 代表单键或双键，a 代表单键（与 a 结合的两个碳原子结合形成单键）或氧原子，或其药学上可接受的盐。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• TETRAHYDRO-PYRROLIZINONE COMPOUNDS AS LFA-I MEDIATORS
  申请人：Novartis AG

  公开号：EP1937685A1

  公开（公告）日：2008-07-02
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：ENEVOLV, INC.

  公开号：US20160186168A1

  公开（公告）日：2016-06-30

  The present disclosure provides compositions and methods for genomic engineering.
• US6869971B1
  申请人：——

  公开号：US6869971B1

  公开（公告）日：2005-03-22

表征谱图