2-[4-[3-(3,4-Dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-2-methoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 木脂素苷
• 英文名称: 2-[4-[3-(3,4-Dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-2-methoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₂₇H₃₄O₁₁
• 分子量: 534.6
• InChiKey: KFFCKOBAHMGTMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  146
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• Compositions and methods for treating hemorrhagic virus infections and other disorders
  申请人：——

  公开号：US20020077276A1

  公开（公告）日：2002-06-20

  Cytokine-receptor and cytokine antagonist-enriched blood-dervided compositions and methods of preparing and using the compositions are provided. Also provided are compositions and methods for the treatment or prevention of disorders, especially acute inflammatory disorders involving pathological responses of the immune system, such as viral hemorrhagic diseases, sepsis, rheumatoid arthritis and other autoimmune disorders, acute cardiovascular events, flare-ups and acute phases of multiple sclerosis, wasting disorders and other disorders involving deleterious expression of cytokines and other factors, including tumor necrosis factor (TNF) and interleukin-1 (IL-1) are provided.

  提供了富含细胞因子受体和细胞因子拮抗剂的血液衍生物组合物的制备和使用方法。还提供了用于治疗或预防疾病的组合物和方法，特别是涉及免疫系统病理反应的急性炎症性疾病，如病毒性出血热疾病、败血症、类风湿关节炎和其他自身免疫性疾病、急性心血管事件、多发性硬化的急性阶段、消耗性疾病和其他涉及细胞因子和其他因子有害表达的疾病，包括肿瘤坏死因子（TNF）和白细胞介素-1（IL-1）。
• Composition comprising extracts of flos lonicerae, fructus forsythiae and radix scutellariae, uses and preparation thereof
  申请人：——

  公开号：US20020168426A1

  公开（公告）日：2002-11-14

  The invention provides a new formulation of the composition comprising Flos Lonicerae Fructus Forsythiae and Radix Scutellariae. This invention also provides a method for identification with HPLC and the characteristic peaks of the compositions of said composition. The composition possesses antiviral effective, namely, inhibition of influenza virus, parainfluenza virus, herpes I virus and herpes II virus. The invention refers to a method for preparation and control of the active components of Flos Lonicerae Fructus Forsythiae and Radix Scutellariae for its biological activity. The invention also provides a unique raw materials and intermediate formulation.

  本发明提供了一种新的组合物配方，包括金银花、连翘和黄芩根。本发明还提供了一种利用高效液相色谱法鉴定所述组合物配方的特征峰的方法。该组合物具有抗病毒作用，即能够抑制流感病毒、副流感病毒、单纯疱疹病毒I和单纯疱疹病毒II。本发明涉及一种制备和控制金银花、连翘和黄芩根的活性成分生物活性的方法。本发明还提供了一种独特的原材料和中间体配方。
• Coagulant for separating serum or plasma from whole blood for use in blood examination procedures
  申请人：Nippon Paint Co., Ltd.

  公开号：EP0196533A1

  公开（公告）日：1986-10-08

  A coagulant or hemostatic comprises, as an effective ingredient, at least one compound consisting of a lignan skelton having oxygen-containing side chains or rings:

  凝血剂或止血剂作为有效成分，至少包含一种由木质素蛋白胨组成的化合物，该蛋白胨具有含氧侧链或环：
• CHEMICAL SYNTHESIS METHOD FOR PHILLYRIN
  申请人：Fu, Li

  公开号：EP3178834A1

  公开（公告）日：2017-06-14

  The present invention relates to a chemical synthesis method for phillyrin. The method of the present invention comprises: first dissolving a glycosyl receptor phillygenin and a glycosyl donor in an organic solvent for glycosylation to obtain tetraacyl phillyrin; then dissolving the tetraacyl phillyrin in a second organic solvent, and adding sodium methoxide for deacylation, adding an acidic pH regulator to regulate the pH value of the reaction mixture to neutral; and finally carrying out purification treatment to obtain phillyrin. The advantages and practical values of the chemical synthesis method for phillyrin of the present invention lie in: the raw material is easy to get, the catalysts used for glycosylation are cheap and easy to get, the production cost is greatly reduced, and it can be used for industrial production.

  本发明涉及一种飞利灵的化学合成方法。本发明的方法包括：首先将糖基受体飞利灵和糖基供体溶解在有机溶剂中进行糖基化反应，得到四酰基飞利灵；然后将四酰基飞利灵溶解在第二种有机溶剂中，加入甲醇钠进行脱酰基反应，加入酸性pH调节剂调节反应混合物的pH值至中性；最后进行纯化处理得到飞利灵。本发明的飞利灵化学合成方法的优点和实用价值在于：原料易得，用于糖基化的催化剂廉价易得，生产成本大大降低，可用于工业化生产。
• APPLICATIONS OF PHILLYRIN/PHILLYGENIN COMPOSITION IN PREPARING DRUGS OR HEALTH CARE PRODUCTS FOR RELIEVING AND/OR TREATING VIRAL DISEASES
  申请人：Fu, Li

  公开号：EP3178482A1

  公开（公告）日：2017-06-14

  The present invention discloses a new application of a composition of phillyrin and phillygeninin in the preparation of drugs for alleviating or/and treating viral diseases. Experiments prove that the composition of phillyrin and phillygeninin has significant treatment effects on viral influenza and pneumonia, as well as on respiratory syncytial viruses, enteroviruses, herpes zoster simplex viruses, Coxsackie viruses, and the like. This composition is characterized by quick action and less toxic and side effects, and thus is an antiviral drug and health product with safety, high efficiency, stability and simple preparation process, and is suitable for industrial production and easy to promote. The present invention provides a new drug, health product and raw material for preventing and treating various viral diseases.

  本发明公开了一种新的应用，即在制备用于缓解或/和治疗病毒性疾病的药物时，使用菲力苷和菲力苷元的组合物。实验证明，菲利蛋白和菲利甙元组合物对病毒性流感和肺炎，以及呼吸道合胞病毒、肠道病毒、带状疱疹病毒、柯萨奇病毒等有显著的治疗效果。该组合物具有作用快、毒副作用小的特点，是一种安全、高效、稳定、制备工艺简单的抗病毒药物和保健品，适合工业化生产，易于推广。本发明提供了一种预防和治疗各种病毒性疾病的新药、保健品和原料。