S-adenosylmethionine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: S-adenosylmethionine
• 英文别名: SAM；s-adenosyl-l-methionine；S-(5′-adenosyl)-L-methionine；4-[[5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-methylsulfonio]-2-azaniumylbutanoate
• 化学式: C₁₅H₂₃N₆O₅S
• 分子量: 399.451
• InChiKey: MEFKEPWMEQBLKI-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  184
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  S-adenosylmethionine 在 ammonium hexafluorophosphate 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  一种半质子型化合物的制备方法及其产品和应用

  摘要：

  本发明涉及一种半质子型化合物的制备方法及其产品和应用，属于化合物制备技术领域。本发明公开了一种半质子型化合物的制备方法，通过将杂烷基有机化合物或杂环有机化合物在铵盐的作用下反应，制备生成含有半质子型化合物。该类化合物的合成方法如通式所示。该半质子型化合物的制备方法简单，得到的半质子型化合物具有还原性、抗菌和抗肿瘤等生物学活性。

  公开号：

  CN113620883B

文献信息

• Inhibitors of DNA Methyltransferase
  申请人：Wahhab Amal

  公开号：US20080132525A1

  公开（公告）日：2008-06-05

  The invention relates to the inhibition of DNA methyltransferase isoforms DNMT1 and DNMT3b2. The invention provides compounds and methods for inhibiting DNMT1 and DNMT3b2.

  这项发明涉及抑制DNA甲基转移酶亚型DNMT1和DNMT3b2。该发明提供了用于抑制DNMT1和DNMT3b2的化合物和方法。
• Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
  申请人：Freedman Joshua

  公开号：US20080206333A1

  公开（公告）日：2008-08-28

  Extended release formulations of S-methyladenosylmethionine (SAMe) are provided, as are methods of treating various disorders using extended release SAMe formulations. The extended release formulations may be used to treat a variety of disorders, including liver disorders, psychiatric disorders and joint disorders. Thus, extended release SAMe formulations may be used to treat alcoholic liver disease, fatty liver disease, hepatitis, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, and depressive disorders such as depression (e.g. major clinical depression) and dysthymia.
• Genetically-modified strain of yeast with an increased production and output of s-adenosylmethionine (sam)
  申请人：Thomas Dominique

  公开号：US20100150871A1

  公开（公告）日：2010-06-17

  The invention relates to a genetically-modified strain of yeast, in which the gene coding for adenosine kinase has been inactivated by genetic modification for the production of S-adenosylmethionine (SAM).
• ANTIGEN-BINDING MOLECULE CONTAINING ANTIGEN-BINDING DOMAIN OF WHICH BINDING ACTIVITY TO ANTIGEN IS CHANGED DEPENDING ON MTA, AND LIBRARY FOR OBTAINING SAID ANTIGEN-BINDING DOMAIN
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US20220153875A1

  公开（公告）日：2022-05-19

  An objective of the present invention is to provide antigen-binding molecules whose antigen-binding activity changes depending on the concentration of a small molecule compound specific to a target tissue, polynucleotides encoding the antigen-binding molecules, vectors containing the polynucleotides, cells carrying the vectors, libraries containing a plurality of the antigen-binding molecules that are different from one another, pharmaceutical compositions containing the antigen-binding molecules, methods of screening for the antigen-binding molecules, methods of producing the same, and the like. The present inventors discovered methylthioadenosine (MTA) as a small molecule compound specific to tumor tissue and created an antigen-binding domain whose antigen-binding activity changes depending on the concentration of MTA, or an antigen-binding molecule containing the antigen-binding domain, and also created a library containing a plurality of antigen-binding domains or antigen-binding molecules containing the antigen-binding domains that are different from one another and discovered that the above objective can be achieved by using the library. By using the antigen-binding molecules of the present disclosure, various diseases (for example, cancer) caused by target tissues (for example, tumor tissues) can be treated in a target tissue-specific manner.
• 一种半质子型化合物的制备方法及其产品和应用
  申请人：西南大学

  公开号：CN113620883B

  公开（公告）日：2023-04-11

  本发明涉及一种半质子型化合物的制备方法及其产品和应用，属于化合物制备技术领域。本发明公开了一种半质子型化合物的制备方法，通过将杂烷基有机化合物或杂环有机化合物在铵盐的作用下反应，制备生成含有半质子型化合物。该类化合物的合成方法如通式所示。该半质子型化合物的制备方法简单，得到的半质子型化合物具有还原性、抗菌和抗肿瘤等生物学活性。