3-Methyl-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 3-Methyl-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxylic acid
• 化学式: C₁₀H₁₂O₂S
• 分子量: 196.27
• InChiKey: MUSYKEZISZZBFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SPIRO-RING COMPOUND
  申请人：Fukatsu Kohji

  公开号：US20100093777A1

  公开（公告）日：2010-04-15

  The present invention aims to provide a compound having an acetyl-CoA carboxylase (ACC) inhibitory action, which is useful for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer and the like, and has superior efficacy. The present invention provides a compound represented by the formula (I): wherein R 1 is a hydrogen atom or a substituent; ring P is an optionally substituted 6-membered nitrogen-containing aromatic heterocycle; ring Q is an optionally further substituted 5- to 7-membered nitrogen-containing non-aromatic heterocycle; and ring R is an optionally fused 5- to 7-membered non-aromatic ring, which is further optionally substituted, or a salt thereof.

  本发明旨在提供一种具有乙酰辅酶A羧化酶（ACC）抑制作用的化合物，该化合物对于预防或治疗肥胖症、糖尿病、高血压、高脂血症、心衰、糖尿病并发症、代谢综合征、肌肉萎缩、癌症等具有优异的疗效。本发明提供的化合物由式（I）表示：其中，R1是氢原子或取代基；环P是可选取代的含氮芳香杂环；环Q是可选进一步取代的5-至7-成员的含氮非芳香杂环；环R是可选融合的5-至7-成员的非芳香环，进一步可选取代，或其盐。