13-oxoprotopine | 15211-02-6

分子结构分类

有机化合物 - 生物碱及其衍生物 - 普罗托品类生物碱

中文名称

——

中文别名

——

英文名称

13-oxoprotopine

英文别名

15-Methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaene-2,3-dione；15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaene-2,3-dione

CAS

15211-02-6

化学式

C₂₀H₁₇NO₆

mdl

——

分子量

367.358

InChiKey

MVLGCIMOMXBFEG-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

2.4
重原子数：

27
可旋转键数：

0
环数：

5.0
sp3杂化的碳原子比例：

0.3
拓扑面积：

74.3
氢给体数：

0
氢受体数：

7

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
原阿片碱	protopine	130-86-9	C₂₀H₁₉NO₅	353.375

反应信息

作为产物：

描述：

原阿片碱在碘作用下，以乙醇为溶剂，以86%的产率得到13-oxoprotopine

参考文献：

名称：

New Contributions to Protopine Chemistry

摘要：

DOI：

10.3987/r-1986-01-0005

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同类化合物

隐掌叶防己碱隐品碱紫菫醚紫堇文碱盐酸前鸦片碱原阿片碱别隐品碱伪原阿片碱 5,7,8,15-四氢-4-羟基-3-甲氧基-6-甲基(1,3)苯并二氧戊环并(5,6-e)(2)苯并氮杂环癸烷-14(6H)-酮 1-甲氧基别隐品碱 3,4-dimethoxy-6-methyl-5,7,8,15-tetrahydro-6H-benzo[c][1,3]dioxolo[4',5':4,5]benz[1,2-g]azecin-14-one; hydrochloride tert-butyl (2S,3S)-2-(8-(benzyloxy)-1,5-dihydroxy-3-methyl-7,12-dioxobenzo[b]phenanthridin-6(5H,7H,12H)-yl)-3-methylpentanoate corycavidine corycavamine Corycavidine hydrochloride 5,6,7,8,13,14-hexahydro-7-methyl-2,3-dimethoxydibenzazecin-14-one 12-bromo-7-methyl-2,3,9,10-tetramethoxy-5,6,7,8,13,14-hexahydrodibenz[c,g]azecine-8,14-dione 12-bromo-5,6,7,8,13,14-hexahydro-7-methyl-2,3,9,10-bis(methylenedioxy)dibenz[c,g]azecine-8,14-dione Protopine-M (demethylene-methyl-) isomer-2, AC 7,8-dimethoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.04,9.016,20]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one;3-O-(2-methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Protopine-M (demethylene-methyl-) isomer-1, AC 6-Hydroxy-allocryptopine (3R)-7,8-dimethoxy-3,11-dimethyl-17,19-dioxa-11-azatetracyclo[12.7.0.04,9.016,20]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one;(3S)-7,8-dimethoxy-3,11-dimethyl-17,19-dioxa-11-azatetracyclo[12.7.0.04,9.016,20]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one (2R)-2,15-dimethyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-one;(2S)-2,15-dimethyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-one 5,6,7,8,13,14-hexahydro-7-methyldibenzazecin-14-one 4-[[8-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-1-hydroxy-5-methoxy-3-methyl-7,12-dioxo-5H-benzo[b]phenanthridin-6-yl]methyl]benzoic acid (±)-corycavidine (+/-)-corycavine 3-[[5-(carboxymethyl)-8-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-1-hydroxy-3-methyl-7,12-dioxo-5H-benzo[b]phenanthridin-6-yl]methyl]benzoic acid 3-[[8-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-1-hydroxy-5-methoxy-3-methyl-7,12-dioxo-5H-benzo[b]phenanthridin-6-yl]methyl]benzoic acid 13-oxocryptopine Coulteropin 3,10-dimethoxy-14H-benzo[e][2]benzazecin-13-one 6-Hydroxyprotopine 13-Oxo-muramin 4-[[8-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-1,5-dihydroxy-3-methyl-7,12-dioxo-5H-benzo[b]phenanthridin-6-yl]methyl]benzoic acid 3,10-dihydroxy-14H-benzo[e][2]benzazecin-13-one 7,8,21-Trimethoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.04,9.016,20]henicosa-1(21),4(9),5,7,14,16(20)-hexaene-2,3-dione 4-[[5-(2-carboxy-2-oxoethyl)-8-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-1-hydroxy-3-methyl-7,12-dioxo-5H-benzo[b]phenanthridin-6-yl]methyl]benzoic acid 4-Hydroxy-3,10,11-trimethoxy-6-methyl-5,7,8,14-tetrahydrobenzo[e][2]benzazecin-13-one 6,7-Dimethoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.04,9.016,20]henicosa-1(21),4,6,8,14,16(20)-hexaene-2,3-dione 7,8-Dihydroxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.04,9.016,20]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one argemexicaine A 13-oxoprotopine 8-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-1-hydroxy-5-methoxy-3-methyl-6-(2-oxopiperidin-3-yl)-5H-benzo[b]phenanthridine-7,12-dione 9-demethylallocryptopine 1,2-Dimethoxy-7-methyl-5H,6H,8H,11H,14H-benzo[1'',2''-4',5']azecino[9',8'-2,1]benzo[4,5-d]1,3-dioxolan-15-one 5,6-dihydro-3,5-di-O-methylconstrictosine leptocarpine 12-Methyl-6,8,18,20-tetraoxa-12-azahexacyclo[11.11.0.02,10.05,9.015,23.017,21]tetracosa-2(10),3,5(9),15,17(21),22-hexaen-24-one