9-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-3H-benzo[f][2]benzofuran-1-one

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 木脂素苷
• 英文名称: 9-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-3H-benzo[f][2]benzofuran-1-one
• 化学式: C₂₇H₂₆O₁₁
• 分子量: 526.5
• InChiKey: NLWUWPJUIJTHAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  38
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• ARYL NAPHTHALIDE LIGNANS AS ANTI-HIV AGENTS
  申请人：The Board of Trustees of the University of Illinois

  公开号：EP2736903B1

  公开（公告）日：2016-06-22
• [EN] GLYCOSYLATED DIPHYLLIN AS A BROAD-SPECTRUM ANTIVIRAL AGENT AGAINST ZIKA VIRUS AND COVID-19<br/>[FR] DIPHYLLINE GLYCOSYLÉE UTILISÉE EN TANT QU'AGENT ANTIVIRAL À LARGE SPECTRE CONTRE LE VIRUS ZIKA ET LA COVID-19
  申请人：ALBERT EINSTEIN COLLEGE OF MEDICINE

  公开号：WO2021041852A1

  公开（公告）日：2021-03-04

  The disclosure provides a method for preventing or treating a flavivirus infection, a filovirus infection, a SARS-CoV-1 infection, a SARS-CoV-2 infection, or a MERS-CoV infection, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof. The disclosure also provides a method for preventing or treating a filovirus infection, a SARS-CoV-1 infection, a SARS-CoV-2 infection, or a MERS-CoV infection with a compound of Formula II or pharmaceutically acceptable salt thereof. The structures of Formula I and Formula II are shown below.